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Emodin

Cat. No. M7790
Emodin Structure
Synonym:

Frangula emodin

Size Price Availability Quantity
50mg USD 40  USD40 In stock
100mg USD 60  USD60 In stock
500mg USD 180  USD180 In stock
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Quality Control & Documentation
Biological Activity

Emodin is an anti-SARS-CoV compound that blocks the interaction between the SARS-coronavirus spike protein and angiotensin converting enzyme 2 (ACE2). Emodin inhibited casein kinase 2 (CK2) and 11β-HSD1. Emodin can also induce necrotic apoptosis of glioma U251 cells and inhibit U251 cell proliferation by targeting the TNF/RIPK1/RIPK3 signaling pathway.


Chemical Information
Molecular Weight 270.24
Formula C15H10O5
CAS Number 518-82-1
Solubility (25°C) DMSO ≥ 9 mg/mL (Need ultrasonic and warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xinxing Li, et al. BMC Cancer. Emodin enhances cisplatin-induced cytotoxicity in human bladder cancer cells through ROS elevation and MRP1 downregulation

[2] Jie-yu Xing, et al. PLoS One. Antitumor Effects and Mechanism of Novel Emodin Rhamnoside Derivatives against Human Cancer Cells In Vitro

[3] Tin-Yun Ho, et al. Antiviral Res. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction

[4] H Yim, et al. Planta Med. Emodin, an anthraquinone derivative isolated from the rhizomes of Rheum palmatum, selectively inhibits the activity of casein kinase II as a competitive inhibitor

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Keywords: Emodin, Frangula emodin supplier, Casein Kinase, inhibitors, activators


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