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Histamine dihydrochloride

Cat. No. M2756
Histamine dihydrochloride Structure
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500mg USD 50  USD50 In stock
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Biological Activity

Histamine 2HCl is an endogenous ligand for the histamine receptor, which can cause allergic reactions by interacting with H1 receptors, promote acid secretion by interacting with H2 receptors, as well as inhibit histamine release and modulate immune responses by interacting with H3 receptors and H4 receptors. It can be used in studies related to allergy, hyperacidity, sleep disorders, asthma and many other diseases.

Chemical Information
Molecular Weight 184.07
Formula C5H9N3.2HCl
CAS Number 56-92-8
Solubility (25°C) Water ≥ 30 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hanna Grauers Wiktorin, et al. Histamine targets myeloid-derived suppressor cells and improves the anti-tumor efficacy of PD-1/PD-L1 checkpoint blockade

[2] E Kovacova-Hanuskova, et al. Histamine, histamine intoxication and intolerance

[3] Lily P H Yang, et al. Histamine dihydrochloride: in the management of acute myeloid leukaemia

[4] Jolanta B Perz, et al. Histamine dihydrochloride for the treatment of acute myeloid leukemia, malignant melanoma and renal cell carcinoma

[5] Carlos M Galmarini. Histamine dihydrochloride (subcutaneous) Maxim

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