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1-methyltryptophan (1 MT) is currently the most widely used IDO1 inhibitor with moderate inhibitory activity. However, the two stereoisomers of 1-mt exhibit different potency :(I) d-1 MT(1) is in phase iii clinical trials as an inhibitor of the Trp -- Kyn pathway, but does not inhibit IDO1 in vitro; (ii)L-1 MT(8), as a competitive substrate inhibitor of L-tryptophan, has moderate inhibitory activity against IDO1 (hIDO1 IC50=42μM, HeLa IDO1 IC50=18.4μM).
| Molecular Weight | 218.25 |
| Formula | C12H14N2O2 |
| CAS Number | 26988-72-7 |
| Solubility (25°C) | Water：2.5 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
| Related IDO Products |
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| (S)-LY-3381916
(S)-LY-3381916 is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC50 value less than 1.5 µΜ. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1. |
| IDO2-IN-1
IDO2-IN-1 is an orally active and potent Indoleamine 2,3-dioxygenase 2 (IDO2) inhibitor with an IC50 value of 112 nM. IDO2-IN-1 can be used for the research of inflammatory autoimmunity. |
| IDO1/2-IN-1
IDO1/2-IN-1 is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. |
| IDO1/2-IN-1 hydrochloride
IDO1/2-IN-1 hydrochloride is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. |
| IDO-IN-18
IDO-IN-18 is an IDO inhibitor. |
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