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Coptisine

Cat. No. M4408
Coptisine Structure
Synonym:

Coptisin

Size Price Availability Quantity
20mg USD 150  USD150 In stock
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Quality Control & Documentation
Biological Activity

Coptisine, an alkaloid isolated from Coptis, is an effective non-competitive IDO inhibitor with Ki value of 5.8 μM and IC50 value of 6.3 μM.

Chemical Information
Molecular Weight 320.32
Formula C19H14NO4+
CAS Number 3486-66-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yan Zhou, et al. Coptisine Attenuates Diabetes-Associated Endothelial Dysfunction through Inhibition of Endoplasmic Reticulum Stress and Oxidative Stress

[2] So Young Kim, et al. Coptisine induces autophagic cell death through down-regulation of PI3K/Akt/mTOR signaling pathway and up-regulation of ROS-mediated mitochondrial dysfunction in hepatocellular carcinoma Hep3B cells

[3] Shengmei Sun, et al. Coptisine alleviates ischemia/reperfusion-induced myocardial damage by regulating apoptosis-related proteins

[4] Jiasi Wu, et al. Coptisine from Coptis chinensis exerts diverse beneficial properties: A concise review

[5] Ya-Li Zhang, et al. Coptisine suppresses proliferation and inhibits metastasis in human pancreatic cancer PANC-1 cells

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  Catalog
Abmole Inhibitor Catalog




Keywords: Coptisine, Coptisin supplier, IDO, inhibitors, activators


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