About 30 results found for searched term "IDO" (0.003 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1695 | Cidofovir | Anti-infection |
| Vistide; GS 0504; HPMPC | ||
| Cidofovir (Vistide) is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis. | ||
| M1710 | Flavopiridol | CDK |
| HMR-1275; Alvocidib; L86-8275 | ||
| Flavopiridol (Alvocidib) is a competitive broad-spectrum CDK inhibitor with IC50 of 30,170,100 nM against CDK1, CDK2 and CDK4, respectively. | ||
| M1962 | Lenalidomide | TNF Receptor |
| Revlimid, CC-5013 | ||
| Lenalidomide is a thalidomide analog known to display TNF-α secretion inhibition and possesses immunomodulatory properties. | ||
| M1976 | Pomalidomide | Ligand for E3 Ligase |
| Actimid, CC-4047 | ||
| Pomalidomide is the third-generation immunomodulatory agent, functions through interacting with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors. Pomalidomide is a second generation immunomodulator, TNF-α inhibitor with IC50 of 13 nM. | ||
| M2225 | Thalidomide | Ligand for E3 Ligase |
| Thalomid | ||
| Thalidomide is a sedative and immunomodulator used to study the symptoms of many cancers, it has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM. | ||
| M2262 | Mianserin hydrochloride | 5-HT Receptor |
| Bolvidon, Norval | ||
| Mianserin HCl is a tetracyclic antidepressant compound. | ||
| M2327 | Daunorubicin hydrochloride | DNA/RNA Synthesis |
| Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride | ||
| Daunorubicin (Daunomycin) HCl is a topoisomerase II inhibitor, inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. | ||
| M2328 | Pirfenidone | TGF-beta/Smad |
| AMR69; S-7701 | ||
| Pirfenidone (AMR69) is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone inhibits TGF-β bioactivity by affecting TGF-β2 mRNA expression and processing of pro-TGF-β in CCL-64 cells. Pirfenidone (AMR69) attenuates CCL2 and CCL12 production in fibrocyte cells. | ||
| M2513 | Chlorthalidone | Sodium Channel |
| Chlortalidone | ||
| Chlorthalidone is a thiazide-like diuretic, it has potential for the research of hypertension. | ||
| M2531 | Clopidol | Parasite |
| WR-61112 | ||
| Clopidol is an antiprotozoal agent. | ||
| M2568 | IDO-IN-2 (NLG-919 Analogue) | IDO |
| GDC-0919 analogue | ||
| NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM. | ||
| M2655 | Droperidol | Dopamine Receptor |
| Dehydrobenzperidol | ||
| Droperidol is a potent antagonist of dopamine subtype 2 receptors in the limbic system. | ||
| M2657 | Droxidopa | Adrenergic Receptor |
| L-DOPS | ||
| Droxidopa is a psychoactive compound and acts as a procompound to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). | ||
| M2720 | IDO5L | IDO |
| INCB14943; INCB024360 analogue | ||
| IDO5L is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 67 nM. | ||
| M58372 | (S)-LY-3381916 | IDO |
| (S)-IDO1-IN-5 | ||
| (S)-LY-3381916 is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC50 value less than 1.5 µΜ. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1. | ||
| M2724 | Gliquidone | Potassium Channel |
| Glurenorm | ||
| Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM. | ||
| M2825 | Lurasidone hydrochloride | 5-HT Receptor |
| SM-13496 | ||
| Lurasidone is an atypical antipsychotic, inhibits Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively. | ||
| M2850 | Midostaurin | PKC |
| PKC412 | ||
| Midostaurin (pkc412) is a multi-targeted kinase inhibitor, including PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50 ranging from 80-500 nM. | ||
| M2921 | Penfluridol | Calcium Channel |
| R-16341 | ||
| Penfluridol is a highly potent, first generation diphenylbutylpiperidine antipsychotic. | ||
| M2942 | Pidotimod | Antibiotic |
| Pidotimod is an immunostimulant. | ||
| M2970 | Pyridoxine hydrochloride | Others |
| Vitamin B6 | ||
| Pyridoxine hydrochloride is a form of vitamin B6. | ||
| M3205 | Zidovudine | Reverse Transcriptase |
| Azidothymidine; AZT; ZDV | ||
| Zidovudine is a reverse transcriptase inhibitor. | ||
| M3260 | Carbidopa | Aryl hydrocarbon Receptor |
| (S)-(-)-Carbidopa | ||
| Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM. | ||
| M3301 | Acetaminophen | Animal Modeling |
| APAP; Paracetamol; Tylenol; 4-Acetamidophenol | ||
| Acetaminophen is a COX inhibitor for COX-1 and COX-2 with IC50 of 113.7 μM and 25.8 μM, respectively. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M3338 | Domperidone | Dopamine Receptor |
| R33812 | ||
| Domperidone is a dopamine blocker and an antidopaminergic reagent. | ||
| M3345 | Primidone | Calcium Channel |
| NCI-C56360 | ||
| Primidone is an anticonvulsant of the pyrimidinedione class. Primidone is a neuronal voltage-gated sodium channel (VGSC) blocker and can be used for the study of epilepsy, essential tremor, and Psychiatric disorders. | ||
| M3393 | Pyridostigmine Bromide | AChR/AChE |
| Pyridostigmine Bromide is a parasympathomimetic and a reversible cholinesterase inhibitor. | ||
| M3483 | Flavopiridol hydrochloride | CDK |
| NSC 649890 HCl; Alvocidib hydrochloride; L86 8275 HCl; HMR-1275 HCl | ||
| Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. | ||
| M3280 | Clopidogrel | P2 Receptor |
| SR-25990C; Clopidogrelum | ||
| Clopidogrel is an oral, thienopyridine class antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease. | ||
| M3737 | Pyridone 6 | JAK |
| Merck-5, CMP 6, JAK Inhibitor I | ||
| Pyridone 6 is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK1 (IC50 = 15 nM for murine JAK1), JAK2 (IC50 = 1 nM), JAK3 (Ki = 5 nM), and Tyk 2 (IC50 = 1 nM) (Janus protein tyrosine kinases). | ||
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