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Flavopiridol (Alvocidib) is a competitive broad-spectrum CDK inhibitor with IC50 of 30,170,100 nM against CDK1, CDK2 and CDK4, respectively.
Front Cell Neurosci. 2021 Oct 1;15:735723.
The Expression and Roles of the Super Elongation Complex in Mouse Cochlear Lgr5+ Progenitor Cells
Flavopiridol purchased from AbMole
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Source | Front Cell Neurosci. 2021 Oct. Figure 4. flavopiridol (Abmole Bioscience, USA) |
| Method | mice treatment | |
| Cell Lines | Lgr5+ cells | |
| Concentrations | 10 μM | |
| Incubation Time | 5 days | |
| Results | The flavopiridol treatment decreased both the number (Figure 4c) and diameter of the spheres (Figure 4d), which suggested that inhibition of the SEC could decrease the sphere-forming ability and proliferation ability of Lgr5+ progenitors in vitro. |
| Cell Experiment | |
|---|---|
| Cell lines | ovarian tumor cell line A2780/ DDP-S |
| Preparation method | 72 h Proliferation Assay. In vitro cytotoxicity was assessed in tissue culture cells by MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfenyl)-2H-tetrazolium, inner salt) assay as previously described.23 Depending upon the cell line used, cells were plated at a density of 3000- 6000 cells/well, in a 96 well plate, and 24 h later, drugs were added and serial-diluted. The cells were incubated at 37 °C for 72 h at which time the tetrazolium dye, MTS in combination with phenazine methosulfate, was added. After 3 h, the absorbency was measured at 492 nm, which is proportional to the number of viable cells. The results are expressed as IC50 values. |
| Concentrations | 0~10 μM |
| Incubation time | 72 h |
| Animal Experiment | |
|---|---|
| Animal models | A2780 human ovarian carcinoma xenograft model in nude mice |
| Formulation | dissolved in a mixture of Cremophor/ ethanol (50:50) , final dilution to the required dosage strength was made with water |
| Dosages | 7.5mg/kg qdx8 |
| Administration | i.p. |
| Molecular Weight | 401.84 |
| Formula | C21H20ClNO5 |
| CAS Number | 146426-40-6 |
| Solubility (25°C) | DMSO 15 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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