Free shipping on all orders over $ 500

NLG919 (Navoximod)

Cat. No. M2568
NLG919 (Navoximod) Structure
Synonym:

Navoximod; GDC-0919

Size Price Availability Quantity
10mg USD 94.5  USD105 In stock
50mg USD 342  USD380 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 282.38
Formula C18H22N2O
CAS Number 1402836-58-1
Purity >98%
Solubility DMSO 56 mg/mL
Storage at -20°C
References

NLG919/cyclodextrin complexation and anti-cancer therapeutic benefit as a potential immunotherapy in combination with paclitaxel
Jian Xu, et al. Eur J Pharm Sci. 2019 Oct 1;138:105034. PMID: 31382032.

Improved Cancer Immunochemotherapy via Optimal Co-delivery of Chemotherapeutic and Immunomodulatory Agents
Yichao Chen, et al. Mol Pharm. 2018 Nov 5;15(11):5162-5173. PMID: 30222360.

Binary Cooperative Prodrug Nanoparticles Improve Immunotherapy by Synergistically Modulating Immune Tumor Microenvironment
Bing Feng, et al. Adv Mater. 2018 Sep;30(38):e1803001. PMID: 30063262.

Related IDO Products
1-Methyl-L-tryptophan

1-Methyl-L-tryptophan is an inhibitor of indoleamine 2,3-dioxygenase (IDO).

LM10

LM10 is a selective tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively).

Palmatine chloride

Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor.

Indoximod

Indoximod, also known as NLG8189 and D-1MT is an indoleamine 2,3-dioxygenase (IDO) pathway inhibitor with a Ki value of 19 μM.

IDO-IN-1

IDO-IN-1 is a potent and selective indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50 of 59 nM.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: NLG919 (Navoximod), Navoximod; GDC-0919 supplier, IDO, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.