IDO-IN-2 (NLG-919 Analogue)

Cat. No. M2568

All AbMole products are for research use only, cannot be used for human consumption.

Synonym:

GDC-0919 analogue

Size	Price	Availability	Quantity
10mg	USD 50 USD50	In stock
50mg	USD 150 USD150	In stock

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NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with K_i/EC50 of 7 nM/75 nM.

Bioact Mater. 2022 Mar 11;16:107-119.

Remodeling tumor immunosuppressive microenvironment via a novel bioactive nanovaccines potentiates the efficacy of cancer immunotherapy
IDO-IN-2 (NLG-919 Analogue) purchased from AbMole
Mol Pharm. 2018 Nov 5;15(11):5162-5173.

Improved Cancer Immunochemotherapy via Optimal Co-delivery of Chemotherapeutic and Immunomodulatory Agents
IDO-IN-2 (NLG-919 Analogue) purchased from AbMole

Molecular Weight	282.38
Formula	C18H22N2O
CAS Number	1402836-58-1
Solubility (25°C)	DMSO 56 mg/mL
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

Related IDO Products
(S)-LY-3381916 (S)-LY-3381916 is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC50 value less than 1.5 µΜ. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.
IDO2-IN-1 IDO2-IN-1 is an orally active and potent Indoleamine 2,3-dioxygenase 2 (IDO2) inhibitor with an IC50 value of 112 nM. IDO2-IN-1 can be used for the research of inflammatory autoimmunity.
IDO1/2-IN-1 IDO1/2-IN-1 is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively.
IDO1/2-IN-1 hydrochloride IDO1/2-IN-1 hydrochloride is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively.
IDO-IN-18 IDO-IN-18 is an IDO inhibitor.

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