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IDO Indoleamine 2,3-dioxygenase

Inhibitors

Cat.No.  Name Information
M2568 IDO-IN-2 (NLG-919 Analogue) NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM.
M21276 NLG802 NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.
M21233 IDO1/TDO-IN-4 IDO1/TDO-IN-4 is a potent dual IDO1/TDO inhibitor with IC50 values of 3.53 μM (IDO1) and 1.15 μM (TDO). IDO1/TDO-IN-4 forms hydrogen bonds with IDO1 and interacts with TDO in π-π stacking. IDO1/TDO-IN-4 can be used in the study of depression, as well as depression-induced infectious, metabolic and autoimmune diseases.
M14451 IDO-IN-4 IDO-IN-4 is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor, extracted from patent WO2014150677A1, Compound example 1 enantiomer 1.
M13383 (Rac)-Indoximod (Rac)-Indoximod(1-methyl-DL-tryptophan) is an indoleamine 2, 3-dioxygenase (IDO) inhibitor.
M13382 LY-3381916 LY-3381916 (IDO1-IN-5) is a potent IDO1 inhibitor that can penetrate the blood brain barrier. LY-3381916 May show antitumor activity.
M11556 NLG-919 (Navoximod) Navoximod (GDC-0919; Nlg-919) is an effective IDO (indoleamine-(2,3)-dioxygenase) inhibitor with Ki/EC50 of 7 nM/75 nM respectively.
M10799 BMS-986242 BMS-986242 is an orally active, potent and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor. BMS-986242 can be used in cancer research.
M10711 PF-06840003 PF-06840003 (EOS200271) is an orally active selective IDO-1 inhibitor that inhibits hIDO-1, dIDO-1, and mIDO-1IC50 They are 0.41 μM, 0.59 μM, and 1.5 μM.
M10302 1-Methyl-L-tryptophan 1-Methyl-L-tryptophan is an inhibitor of indoleamine 2,3-dioxygenase (IDO).
M10116 LM10 LM10 is a selective tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively).
M9620 Palmatine chloride Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor.
M9085 Indoximod Indoximod, also known as NLG8189 and D-1MT is an indoleamine 2,3-dioxygenase (IDO) pathway inhibitor with a Ki value of 19 μM.
M8944 IDO-IN-1 IDO-IN-1 is a potent and selective indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50 of 59 nM.
M6309 IDO-IN-2 IDO-IN-2 is an IDO inhibitor extracted from patent WO/2015031295 A1, compound example 1, has IC50 values of 0.068 μM in HeLa cell and 0.16 μM in HEK293 cell.
M6248 BMS-986205 (Linrodostat) BMS-986205 (Linrodostat) is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
M6136 Epacadostat Epacadostat (INCB024360) is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM and displays high selectivity over other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO).
M4570 Palmatine Palmatine is an orally active and irreversible IDO-1 inhibitor. Palmatine ameliorates colitis induced by Dextran Sulphate Sodium Salt (DSS) by reducing colon injury, preventing intestinal microbiome imbalance and regulating tryptophan catabolism. Palmatine has potential for colitis research.
M4410 Coptisine-Sulfate Coptisine Sulfate is an alkaloid isolated from coptis coptidis. It is an effective non-competitive IDO inhibitor with Ki value of 5.8 μM and IC50 value of 6.3 μM.
M4409 Coptisine-chloride Coptisine chloride is an effective and non-competitive IDO inhibitor with Ki value of 5.8 μM and IC50 value of 6.3 μM. Coptisine chloride is an effective H1N1 neuraminidase (NA-1) inhibitor with IC50 of 104.6 μg/mL, which can be used for influenza A virus (H1N1) infection.
M4408 Coptisine Coptisine, an alkaloid isolated from Coptis, is an effective non-competitive IDO inhibitor with Ki value of 5.8 μM and IC50 value of 6.3 μM.



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