Free shipping on all orders over $ 500


Cat. No. M10302
1-Methyl-L-tryptophan Structure

(S)-Indoximod; (S)-NLG-8189

Size Price Availability Quantity
50mg USD 32.4  USD36 In stock
100mg USD 43.2  USD48 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

1-Methyl-L-tryptophan is an inhibitor of indoleamine 2,3-dioxygenase (IDO). 1-Methyl-L-tryptophan exhibits inhibition of rabbit small intestine indoleamine 2, 3-dioxygenase, competitive inhibition of IDO, reduction of Foxp3 protein expression in tumor of C57BL/6 mouse allografted with mouse LLC cells at 200 mg/kg.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 218.25
Formula C12H14N2O2
CAS Number 21339-55-9
Purity >99%
Solubility Soluble in methanol
Soluble in dilute acid and dilute alkali
Storage 2-8°C, protect from light, dry, sealed

PEG-Poly(1-Methyl-l-Tryptophan)-Based Polymeric Micelles as Enzymatically Activated Inhibitors of Indoleamine 2,3-Dioxygenase
George Lo Huang, et al. Nanomaterials (Basel). 2019 May 9;9(5):719. PMID: 31075929.

1-L-MT, an IDO inhibitor, prevented colitis-associated cancer by inducing CDC20 inhibition-mediated mitotic death of colon cancer cells
Xiuting Liu, et al. Int J Cancer. 2018 Sep 15;143(6):1516-1529. PMID: 29607498.

Related IDO Products

LM10 is a selective tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively).

Palmatine chloride

Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor.


Indoximod, also known as NLG8189 and D-1MT is an indoleamine 2,3-dioxygenase (IDO) pathway inhibitor with a Ki value of 19 μM.


IDO-IN-1 is a potent and selective indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50 of 59 nM.


IDO-IN-2 is an IDO inhibitor extracted from patent WO/2015031295 A1, compound example 1, has IC50 values of 0.068 μM in HeLa cell and 0.16 μM in HEK293 cell.

Abmole Inhibitor Catalog 2017

Keywords: 1-Methyl-L-tryptophan, (S)-Indoximod; (S)-NLG-8189 supplier, IDO, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.