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BMS-986205 (Linrodostat) is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
| Molecular Weight | 410.91 |
| Formula | C24H24ClFN2O |
| CAS Number | 1923833-60-6 |
| Purity | 99.56% |
| Solubility | DMSO 60 mg/mL |
| Storage | at -20°C |
Discovery of IDO1 Inhibitors: From Bench to Bedside
George C Prendergast, et al. Cancer Res. 2017 Dec 15;77(24):6795-6811. PMID: 29247038.
Blocking IDO1 Helps Shrink Bladder, Cervical Tumors.
Cancer Discov. 2018 Jan;8(1):OF3. PMID: 29167110.
| Related IDO Products |
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| 1-Methyl-L-tryptophan
1-Methyl-L-tryptophan is an inhibitor of indoleamine 2,3-dioxygenase (IDO). |
| LM10
LM10 is a selective tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively). |
| Palmatine chloride
Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor. |
| Indoximod
Indoximod, also known as NLG8189 and D-1MT is an indoleamine 2,3-dioxygenase (IDO) pathway inhibitor with a Ki value of 19 μM. |
| IDO-IN-1
IDO-IN-1 is a potent and selective indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50 of 59 nM. |
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