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BMS-986205 (Linrodostat)

Cat. No. M6248
BMS-986205 (Linrodostat) Structure


Size Price Availability Quantity
10mM*1mL USD 143.1  USD159 In stock
5mg USD 132.3  USD147 In stock
10mg USD 243  USD270 In stock
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Quality Control
Biological Activity

BMS-986205 (Linrodostat) is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 410.91
Formula C24H24ClFN2O
CAS Number 1923833-60-6
Purity 99.56%
Solubility DMSO 60 mg/mL
Storage at -20°C

Discovery of IDO1 Inhibitors: From Bench to Bedside
George C Prendergast, et al. Cancer Res. 2017 Dec 15;77(24):6795-6811. PMID: 29247038.

Blocking IDO1 Helps Shrink Bladder, Cervical Tumors.
Cancer Discov. 2018 Jan;8(1):OF3. PMID: 29167110.

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Abmole Inhibitor Catalog 2017

Keywords: BMS-986205 (Linrodostat), ONO-7701 supplier, IDO, inhibitors

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