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BMS-986205 (Linrodostat)

Cat. No. M6248
BMS-986205 (Linrodostat) Structure


Size Price Availability Quantity
10mM*1mL in DMSO USD 72  USD72 In stock
5mg USD 66  USD66 In stock
10mg USD 100  USD100 In stock
25mg USD 205  USD205 In stock
50mg USD 310  USD310 In stock
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Quality Control
Biological Activity

BMS-986205 (Linrodostat) is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 410.91
Formula C24H24ClFN2O
CAS Number 1923833-60-6
Purity 99.56%
Solubility DMSO 60 mg/mL
Storage at -20°C

[1] George C Prendergast, et al. Cancer Res. Discovery of IDO1 Inhibitors: From Bench to Bedside

[2] Cancer Discov. Blocking IDO1 Helps Shrink Bladder, Cervical Tumors.

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Keywords: BMS-986205 (Linrodostat), ONO-7701 supplier, IDO, inhibitors

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