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IDO-IN-1

Cat. No. M8944
IDO-IN-1 Structure
Size Price Availability Quantity
5mg USD 230  USD230 In stock
10mg USD 385  USD385 In stock
25mg USD 800  USD800 In stock
50mg USD 1020  USD1020 In stock
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Quality Control & Documentation
Biological Activity

IDO-IN-1 is a potent and selective indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50 of 59 nM. In vivo, IDO-IN-1 showed pharmacodynamic activity and efficacy in a mouse melanoma model.

Chemical Information
Molecular Weight 316.09
Formula C9H7BrFN5O2
CAS Number 914638-30-5
Solubility (25°C) DMSO: ≥ 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yue EW, et al. J Med Chem. Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model.

Related IDO Products
IDO-IN-18

IDO-IN-18 is an IDO inhibitor.

IDO1-IN-21

IDO1-IN-21 is an IDO1 inhibitor (IC50 = 0.64 μM).

IDO1-IN-22

IDO1-IN-22 is a IDO1 inhibitor (biochemical hIDO1 IC50: 67.4 nM, HeLa hIDO1 IC50: 17.6 nM).

IDO1/TDO-IN-6

IDO1/TDO-IN-6 is a dual inhibitor of IDO1/TDO with IC50s of 2.25 and 2.89 μM, respectively.

IDO-IN-13 

IDO-IN-13 is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an EC50 of 17 nM, extracted from patent WO2019040102A1, example 43.

  Catalog
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Keywords: IDO-IN-1 supplier, IDO, inhibitors, activators


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