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Palmatine chloride

Cat. No. M9620
Palmatine chloride Structure
Size Price Availability Quantity
250mg USD 49.5  USD55 In stock
500mg USD 72  USD80 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor. Palmatine chloride can ameliorate DSS-induced colitis by mitigating colonic injury, preventing gut microbiota dysbiosis, and regulating tryptophan catabolism. In vivo, Palmatine (50 or 100 mg/kg, oral; 7 days) has less distortion of epithelium, and fewer infiltrations of inflammatory cells, resulting in significantly lower histopathological scores, it also significantly suppresses the colonic MPO activity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 387.86
Formula C21H22ClNO4
CAS Number 10605-02-4
Purity >98%
Solubility Soluble in warm water
Storage 4°C, dry, protect from light, sealed
References

Palmatine ameliorated murine colitis by suppressing tryptophan metabolism and regulating gut microbiota
Xiao-Jun Zhang, et al. Pharmacol Res. 2018 Nov;137:34-46. PMID: 30243842.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Palmatine chloride supplier, IDO, inhibitors

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