Free shipping on all orders over $ 500
About 30 results found for searched term "Proteasome" (0.019 seconds)
| Cat.No. | Name | Information |
|---|---|---|
| M1686 | Bortezomib (PS-341) | Bortezomib (PS-341) is a highly selective proteasome inhibitor with a ki value of 6nM. |
| M1902 | MG132 | MG132 is a specific and potent cell-permeable proteasome inhibitor (IC50 = 100 nM, Ki = 4 nM). |
| M2071 | ONX-0914 | Onx-0914 (PR-957) is a selective inhibitor of low molecular weight polypeptide 7 (LMP7), a chymotrypsin subunit of the immune proteasome. Onx-0914 blocks cytokine production and reduces the progression of experimental arthritis. Onx-0914 is a non-competitive irreversible inhibitor of mycobacterium proteasome (Ki=5.2 μM). Onx-0914 activates latent HIV-1 through HF-1-mediated p-TEFb activation. |
| M2122 | MLN9708 | MLN9708 is a novel orally bioactive proteasome inhibitor, inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC50 value of 3.4 nM. |
| M2150 | Oprozomib | Oprozomib (ONX 0912) is a novel orally proteasome inhibitor with potential antineoplastic activity. |
| M2152 | Carfilzomib | Carfilzomib (PR-171) is an irreversible proteasome inhibitor with an IC50 of <5 nM. Carfilzomib irreverently selectively binds to the active site containing n-terminal threonine of the 20S proteasome and proteolytic core particles of the 26S proteasome.*The compound is unstable in solutions, freshly prepared is recommended. |
| M2166 | Birinapant | Birinapant (TL32711) is a bivalent Smac analogue, which is a potent antagonist of XIAP and cIAP1 with Kd values of 45 nM and less than 1 nM, respectively. Birinapant (TL32711) induces autoubiquitination and proteasome degradation of cIAP1 and cIAP2 in intact cells, resulting in the formation of RIPK1: Caspase-8 complex, which activates and induces tumor cell death. |
| M2193 | Epoxomicin | Epoxomicin is a cell-permeable, novel proteasome inhibitor with an IC50 value of 4 nM. |
| M2285 | MLN2238 | MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM, respectively. |
| M2431 | b-AP15 | b-AP15 is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM. *The compound is unstable in solutions, freshly prepared is recommended |
| M2583 | PD 169316 | PD 169316 is a cell-permeable, potent and selective p38 MAP kinase inhibitor that indirectly activates proteasome activity and has antiviral activity against Enterovirus71 with an IC50 value of 89 nM. |
| M2801 | Lactacystin | Lactacystin is a potent and selective inhibitor of the 20S proteasome. |
| M2807 | LDN-57444 | LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3. |
| M2995 | Salinosporamide A | Salinosporamide A (NPI-0052, Marizomib) is a novel marine derived proteasome inhibitor which inhibits CT-L, C-L, and T-L proteasome activities in human erythrocyte-derived 20S proteasomes with EC50 of 3.5 nM, 430 nM, 28 nM. |
| M3161 | Betulinic acid | Betulinic acid is a natural pentacyclic triterpenoid compound, which is an inhibitor of eukaryotic cell topoisomerase I with IC50 value of 5 μM. It has anti-inflammatory, anti-malaria, anti-AIDS and anti-tumor activities. Betulinic acid(Betulinic acid) is also an agonist of 20S proteasome. EC50=5.5μmol/L, Betulinic acid can specifically enhance cT-L activity of 20S proteasome. |
| M3456 | Chlorpromazine hydrochloride | Chlorpromazine hydrochloride is an antagonist of D2, 5HT2A, potassium and sodium channels. The Ki of Chlorpromazine Hydrochloride to D2 and 5HT2A were 363 nM and 8.3 nM, respectively. Chlorpromazine also excites the 20S proteasome. *The compound is unstable in solutions, freshly prepared is recommended |
| M3476 | CEP-18770 | CEP-18770 is an orally active inhibitor of the chymotrypsin-like activity of proteasome with IC50 of 3.8 nM, with only marginal inhibition of the tryptic and peptidylglutamyl activities of the proteosome. |
| M3884 | Celastrol (Tripterin) | Celastrol (Tripterin) is a potent antioxidant and anti-inflammatory agent, as well as a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM. |
| M4240 | Shikonin | Shikonin (C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844) is an effective and specific inhibitor of Pyruvate kinase M2 (PKM2). Shikonin is the main ingredient of Lithosia, a Chinese herb with a variety of biological activities. Shikonin acts as an anti-inflammatory by inhibiting tumor necrosis factor-α (TNF-α), Proteasome can inhibit the activation of nuclear factor-κB (NF-κB) signaling pathway. |
| M4522 | Ursolic acid | Ursolic acid (Prunol) is a natural triterpenoid carboxylic acid compound with preventive and anticancer activities. Ursolic acid also has proteasome agonist activity, EC50=14μmol/L. |
| M4985 | VR23 | VR23 is a small molecule that potently inhibited the activities of trypsin-like proteasomes (IC50 = 1 nM), chymotrypsin-like proteasomes (IC50 = 50-100 nM), and caspase-like proteasomes (IC50 = 3 μM). |
| M5385 | Acetylcysteine (NAC) | Acetylcysteine (NAC; N-acetyl-l-cysteine) is a ROS inhibitor that antagonizes the activity of several proteasome inhibitors. It is also an inhibitor of the tumor necrosis factor TNF. |
| M5939 | Rolipram | A selective inhibitor of PDE4, Rolipram, inhibits immunopurified PDE4B and PDE4D activity with IC50 of 130 nM and 240 nM, respectively. It has anti-inflammatory activity. Rolipram also increased cAMP levels and activated PKA, which in turn increased proteasome activity and inhibited tau aggregation. |
| M7796 | Fluspirilene | Fluspirilene is a non-competitive L-type calcium channel antagonist (IC50 = 0.03μM). It is also a dopamine receptor antagonist and can be used as a precursor structure for the development of 20S proteasome agonists. |
| M8473 | RA-9 | RA-9 is a cell permeable and potent inhibitor of the ubiquitin-proteasome system (UPS) that targets deubiquitinating enzymes (DUB) without affecting 20S proteasome catalytic-core activity. |
| M9570 | PTP1B-IN-9 | PTP1B-IN-9 is a ubiquitin-proteasome system (UPS)-stressor with anticancer activity. |
| M9577 | RA190 hydrochloride | RA190 HCl is a potent RPN13 and ADRM1 Inhibitor, inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13. |
| M10753 | VLX1570 | VLX1570 is a competitive inhibitor of proteasome deuteronase (DUBs), with IC50 of 10 μM. |
| M10767 | M-3258 | M3258 is an oral bioavailable, potent, reversible, and highly selective immunoproteasome subunit LMP7 (β5i) inhibitor. M3258 for LMP7 IC50 is 3.6 nM in cells IC50 3.4 nM. |
| M10883 | RTS-V5 | RTS-V5 is an inhibitor of HDAC/proteasomes, against HDAC1, HDAC2, HDAC3, HDAC6, HDAC8IC50They were 6.9, 18, 15, 0.27, 0.53 μM, respectively. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.
