Trigonelline-Hydrochloride

Cat. No. M4551

Synonym:

Trigonelline hydrochloride

Size	Price	Availability	Quantity
20mg	USD 40 USD40	In stock

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Quality Control & Documentation

Purity: >99.0%
COA
MSDS

Product Information

Biological Activity

As an NRF2 inhibitor, fenuelline blocks the expression of NRF2 target genes associated with heme and iron metabolism, synergistic with Erastin and sorafenib to promote iron death in hepatocellular carcinoma cells.

Chemical Information

CAS Number	6138-41-6
Form	Solid
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m²)	0.007	0.025	0.15	0.05	0.02	0.5
K_m factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B K_m
	Animal A K_m

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xiao-Yi Li, et al. Inhibitory effect of chloroform extracts from Citrus aurantium L. var. amara Engl. on fat accumulation

[2] Shriya Saha, et al. Leishmania donovani Targets Host Transcription Factor NRF2 To Activate Antioxidant Enzyme HO-1 and Transcriptional Repressor ATF3 for Establishing Infection

[3] Hiroaki Iwamoto, et al. Coffee diterpenes kahweol acetate and cafestol synergistically inhibit the proliferation and migration of prostate cancer cells

[4] K Rasheeda, et al. Trigonelline hydrochloride: A promising inhibitor for type I collagen fibrillation

[5] Richard H Stadler, et al. Alkylpyridiniums. 1. Formation in model systems via thermal degradation of trigonelline

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Trigonelline-Hydrochloride