Free shipping on all orders over $ 500


Cat. No. M2193
Epoxomicin Structure

BU 4061T

Size Price Availability Quantity
1mg USD 123.3  USD137 In stock
5mg USD 360  USD400 In stock
10mg USD 630  USD700 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Epoxomicin (BU 4061T) is a naturally occurring selective proteasome inhibitor with anti-inflammatory activity. Epoxomicin covalently binds to the LMP7, X, MECL1, and Z catalytic subunits of the proteasome. Epoxomicin (BU 4061T) inhibits proteasome activity in cell growth assays with an IC50 value of 4 nM and demonstrates potent cytotoxicity against B16-F10, HCT116, and Moser solid tumor cells, as well as P388 and K562 leukemia cells with IC50 values ranging from 2-44 nM. Epoxomicin also effectively inhibits NF-kappaB activation in vitro and potently blocks in vivo inflammation in the murine ear edema assay. In contrast to peptide aldehyde proteasome inhibitors, epoxomicin does not inhibit nonproteasomal proteases such trypsin, chymotrypsin, papain, calpain, and cathepsin B at concentrations of up to 50 microM. Treatment of proliferating cells with epoxomicin results in cell death through accumulation of ubiquinated proteins.

Product Citations
Customer Product Validations & Biological Datas
Source Mol Cell (2020), Figure 4, Epoxomicin (Abmole Bioscience Inc.)
Method Cell Culture
Cell Lines HeLa and HEK293T cell lines
Concentrations 100 µM
Incubation Time 2-12 hours
Results CCCP treatment induced accumulation of mitochondrion-localized fulllength PINK1 protein and an enhanced p-S222-TUFm signal;applying the proteasome inhibitor MG132 or epoxomicin elevated cytosolic and mitochondrial cleaved PINK1 and the p-S222-TUFm signal, and so did the autophagosome formation inhibitors CK636 and Baf-A1, but to a lesser extent
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 554.72
Formula C28H50N4O7
CAS Number 134381-21-8
Purity 98.57%
Solubility DMSO 10 mg/mL
Storage at -20°C

Evaluation of the in vitro growth-inhibitory effect of epoxomicin on Babesia parasites.
Aboulaila M, et al. Vet Parasitol. 2010 Jan 20;167(1):19-27. PMID: 19896277.

The proteasome inhibitor epoxomicin has potent Plasmodium falciparum gametocytocidal activity.
Czesny B, et al. Antimicrob Agents Chemother. 2009 Oct;53(10):4080-5. PMID: 19651911.

The selective proteasome inhibitors lactacystin and epoxomicin can be used to either up- or down-regulate antigen presentation at nontoxic doses.
Schwarz K, et al. J Immunol. 2000 Jun 15;164(12):6147-57. PMID: 10843664.

Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity.
Meng L, et al. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10403-8. PMID: 10468620.

Related Proteasome Products
RA190 hydrochloride

RA190 HCl is a potent RPN13 and ADRM1 Inhibitor, inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.


PTP1B-IN-9 is a ubiquitin-proteasome system (UPS)-stressor with anticancer activity.

MDL 28170

MDL 28170 is a potent cell permeable calpain I and II inhibitor, it reduces capsaicin-mediated cell death in cultured dorsal root ganglion neurons.

Sivelestat sodium tetrahydrate

Sivelestat sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse.


MG-101 is a potent inhibitor of cysteine proteases including calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM). IC50 value: 150 nM (Ki)

Abmole Inhibitor Catalog 2017

Keywords: Epoxomicin, BU 4061T supplier, Proteasome, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.