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Lactacystin is a potent and selective inhibitor of the 20S proteasome.
| Molecular Weight | 376.43 |
| Formula | C15H24N2O7S |
| CAS Number | 133343-34-7 |
| Solubility (25°C) | DMSO 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Masakatsu Shibasaki, et al. Total synthesis of lactacystin and salinosporamide A
[5] G Fenteany, et al. Lactacystin, proteasome function, and cell fate
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NIC-0102 is an orally potent proteasome inhibitor (pIC50=7.55) that specifically inhibits NLRP3 inflammasome activation.NIC-0102 showed potent anti-inflammatory effects in vivo in a DSS-induced ulcerative colitis model. In addition, NIC-0102 inhibited the production of pro-IL-1β. |
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| PR-39
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