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MLN2238

Cat. No. M2285

All AbMole products are for research use only, cannot be used for human consumption.

MLN2238 Structure
Synonym:

Ixazomib

Size Price Availability Quantity
5mg USD 95  USD95 In stock
10mg USD 140  USD140 In stock
25mg USD 285  USD285 In stock
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Quality Control & Documentation
Biological Activity

MLN2238 is a potent reversible and specific β5 site of the 20S proteasome inhibitor with an IC50 value of 3.4 nM. Proteasome activity was significantly inhibited in both blood and tumor following a single dose of MLN2238 administered IV at 14 mg/kg or SC at 4 mg/kg. It is active in preclinical models of lymphoma, and that MLN2238 has antitumor activity in a model of lymphoma that is refractory to bortezomib treatment.

Customer Product Validations & Biological Datas
Source Cell Death Dis (2018). Figure 5. MLN2238
Method MTS assay
Cell Lines HepG2 a, Hep3B b, and SNU475 c cells
Concentrations 0-1000 nM
Incubation Time 24, 48, and 72 h
Results Fig. 1d shows that after 48 h MLN2238 significantly inhibited HCC cell proliferation according to the drug concentration.
Chemical Information
Molecular Weight 361.03
Formula C14H19BCl2N2O4
CAS Number 1072833-77-2
Solubility (25°C) DMSO 52 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] No authors listed. Ixazomib

[2] Giuseppa Augello, et al. Preclinical evaluation of antitumor activity of the proteasome inhibitor MLN2238 (ixazomib) in hepatocellular carcinoma cells

[3] Xinghua Wei, et al. MLN2238 synergizes BH3 mimetic ABT-263 in castration-resistant prostate cancer cells by induction of NOXA

[4] Aneel Paulus, et al. The investigational agent MLN2238 induces apoptosis and is cytotoxic to CLL cells in vitro, as a single agent and in combination with other drugs

[5] Juan J Gu, et al. MLN2238, a proteasome inhibitor, induces caspase-dependent cell death, cell cycle arrest, and potentiates the cytotoxic activity of chemotherapy agents in rituximab-chemotherapy-sensitive or rituximab-chemotherapy-resistant B-cell lymphoma preclinical mod䲧畸

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Keywords: MLN2238, Ixazomib supplier, Proteasome, inhibitors, activators

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