About 30 results found for searched term "MI-1" (0.007 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1686 | Bortezomib (PS-341) | Proteasome |
| Velcade; PS-341; LDP 341; MG 341; NSC 681239 | ||
| Bortezomib (PS-341) is a highly selective proteasome inhibitor with a ki value of 6nM. | ||
| M1763 | Mirdametinib (PD0325901) | MEK |
| Mirdametinib；PD325901 | ||
| Mirdametinib (PD0325901) is a highly potent and selective MEK inhibitor with an IC50 in C26 cells of 0.33nM. | ||
| M1839 | MDV3100 | Androgen Receptor |
| Enzalutamide; MDV-3100 | ||
| MDV3100 is an orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. | ||
| M1962 | Lenalidomide | TNF Receptor |
| Revlimid, CC-5013 | ||
| Lenalidomide is a thalidomide analog known to display TNF-α secretion inhibition and possesses immunomodulatory properties. | ||
| M2217 | Mitoxantrone dihydrochloride | Topoisomerase |
| Mitozantrone dihydrochloride; NSC 301739 dihydrochloride | ||
| Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. | ||
| M2279 | Citalopram hydrobromide | 5-HT Receptor |
| Celexa; Cipramil; Lu 10-171 | ||
| Citalopram (Celexa, Cipramil) is a selective serotonin reuptake inhibitor (SSRI), selectively inhibits the CNS neuronal reuptake of serotonin, thereby potentiating serotonergic activity in the central nervous system (CNS). | ||
| M2297 | Devimistat (CPI-613) | Dehydrogenase |
| Devimistat | ||
| Devimistat (CPI-613) inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase. | ||
| M2701 | Fidaxomicin | Antibiotic |
| OPT-80; PAR-101; Clostomicin B1; Tiacumicin B | ||
| Fidaxomicin is a narrow spectrum macrocyclic antibiotic that inhibits RNA polymerase sigma subunit. | ||
| M2830 | Mdivi-1 | Dynamin |
| Mitochondrial division inhibitor 1 | ||
| Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM. | ||
| M2870 | MSDC-0160 | Others |
| Mitoglitazone; CAY10415 | ||
| MSDC 0160 (Mitoglitazone) is an insulin sensitizer that regulates the mitochondrial target of thiazolidinedione (mTOT) and a regulator of mitochondrial pyruvate vector (MPC). MSDC 0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities. MSDC 0160 has potential for use in Alzheimer's disease. | ||
| M55629 | MIPS-21335 | PI3K |
| MIPS21335 | ||
| MIPS-21335 is a PI3KC2α inhibitor, with IC50 of 7 nM. MIPS-21335 also inhibits PI3KC2β, p110α, p110β and p110δ with IC50 values of 0.043, 0.140, 0.386, 0.742 μM, respectively. | ||
| M3046 | Tacrine hydrochloride | AChR/AChE |
| Hydroaminacrine; NSC72108 HCl | ||
| Tacrine is a centrally acting anticholinesterase and indirect cholinergic agonist. | ||
| M3118 | Verapamil hydrochloride | Calcium Channel |
| (±)-Verapamil hydrochlorid; CP-16533-1 hydrochloride | ||
| Verapamil hydrochloride (VPH) is an orally active L-type calcium channel inhibitor that eliminates calcium channel agonist-induced calcium inward flow and apoptosis. Verapamil hydrochloride is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor. | ||
| M3238 | 4-Quinazolinamine | EGFR/HER2 |
| 4-Aminoquinazoline, NSC 288012 | ||
| 4-Quinazolinamine (4-Aminoquinazoline) is a potent and highly selective EGFR tyrosine kinase inhibitor. | ||
| M3352 | Lamivudine (BCH-189) | Reverse Transcriptase |
| BCH-189 | ||
| Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI) with an IC50 of 2.7 mM. Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS. | ||
| M3358 | Procainamide hydrochloride | Sodium Channel |
| Procaine amide hydrochloride; SP 100 hydrochloride | ||
| Procainamide hydrochloride is a sodium channel blocker, and also a DNA methyltransferase inhibitor. | ||
| M3379 | Trifluridine | DNA/RNA Synthesis |
| Trifluridine; FTD; 5-Trifluorothymidine; NSC 529182; NSC 75520 | ||
| Trifluridine (Trifluorothymidine) is an irreversible and orally active thymidylate synthase inhibitor, and thereby suppressing DNA synthesis. Trifluridine is an antiviral molecule used for research of HSV, rhabdovirus and orthopoxvirus infection. | ||
| M3380 | Pitavastatin Calcium | Autophagy |
| Pitavastatin hemicalcium; NK-104 | ||
| Pitavastatin Calcium is a new type of statin. | ||
| M3493 | Mitoxantrone | Topoisomerase |
| Mitozantrone; NSC 301739 | ||
| Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively | ||
| M3708 | Anastrozole | Cytochrome P450 (e.g. CYP17) |
| Arimidex, ZD1033 | ||
| Anastrozole is a potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis. | ||
| M1545 | Infliximab | TNF Receptor |
| Remicade; Avakine; CT-P13 | ||
| Infliximab is a purified, recombinant DNA-derived chimeric human-mouse IgG monoclonal antibody that blocks TNF-α interaction with TNF-α receptor 1 (TNFR1) and TNFR2. For the treatment of autoimmune diseases. Infliximab is available in BALB/ C or C57/Bl6 mice. | ||
| M4249 | Schisandrol B | NF-κB |
| Gomisin-A; Besigomsin; schizandrol-B; TJN-101; Wuweizi alcohol-B; Wuweizichun-B | ||
| Schisandrol B is a major active constituent of Schisandra sphenanthera with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities. | ||
| M4253 | (-)Gomisin-L1 | Others |
| (-)Gomisin-L1 | ||
| M4271 | Delavinone | Others |
| Sinpeimine; CAS# 103530-47-8 | ||
| Delavinone | ||
| M4732 | Palmitic acid | Metabolite/Endogenous Metabolite |
| Palmitic Acid (1.00509); Palmitic acid tech; Hexadecan acid | ||
| Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid (PA) can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid can be used to establish a cell steatosis model. | ||
| M4817 | Tacalcitol | Vitamin |
| 1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3 | ||
| Tacalcitol is a synthetic vitamin D3 analog. | ||
| M4822 | Eltrombopag Olamine | Thrombopoietin/Thrombin |
| Eltrombopag diethanolamine salt; SB-497115GR | ||
| Eltrombopag olamine is a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. | ||
| M4907 | Doxycycline Hyclate | MMP |
| Doxycycline hydrochloride hemiethanolate hemihydrate; WC2031 | ||
| Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. | ||
| M4972 | 3-Amino-5-mercapto-1,2,4-triazole | Plant growth regulators |
| Amitrole (3-amino-1,2,4-triazole) is a widely used herbicide. | ||
| M4991 | Dihydroartemisinin | Parasite |
| β-Dihydroartemisinin; DHA; Artenimol; CAS# 81496-82-4 | ||
| Dihydroartemisinin is a potent anti-malaria agent. Dihydroartemisinin, a derivative of artemisinin in which the C-10 lactone group is replaced by hemiacetals and active metabolites of all artemisinin compounds, is a widely used antimalarial compound that effectively induces iron death in acute myeloid leukemia cells (HL60, KG1, and THP-1) by regulating iron metabolism. | ||
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