Tacalcitol has been shown to regulate calcium levels and induce nerve growth factor production in epidermal keratinocytes.Tacalcitol promotes normal bone development by regulating calcium. Tacalcitol modulates immunological and inflammatory processes.Tacalcitol induces nerve growth factor production in epidermal keratinocytes.
| Molecular Weight | 416.64 |
| Formula | C27H44O3 |
| CAS Number | 57333-96-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage | 4°C, protect from light, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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