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Cat. No. M2046
Calcifediol Structure


Size Price Availability Quantity
5mg USD 115 In stock
10mg USD 195 In stock
50mg USD 780 In stock
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Quality Control
Biological Activity

Calcifediol, also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D (abbreviated 25(OH)D), is a major circulating metabolite of vitamin D3 and acts as a competitive inhibitor with an apparent Ki of 3.9 μM. Calcifediol suppresses PTH synthesis and secretion in bovine parathyroid cells with ED50 of 2 nM. Calcifediol is then converted in the kidneys (by the enzyme 25(OH)D-1α-hydroxylase) into calcitriol (1,25-(OH)2D3), a secosteroid hormone that is the active form of vitamin D. It can also be converted into 24-hydroxycalcidiol in the kidneys via 24-hydroxylation. In the pooled analysis, higher circulating 25(OH)D(3) concentrations were statistically significantly associated with decreased colorectal adenoma risk (highest vs. lowest quartile odds ratio = 0.59, 95% confidence interval: 0.41, 0.84).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 400.64
Formula C27H44O2
CAS Number 19356-17-3
Purity 100.00%
Solubility DMSO 72 mg/mL
Ethanol 20 mg/mL
Storage at -20°C

Blood 25-hydroxyvitamin D3 concentrations and incident sporadic colorectal adenoma risk: a pooled case-control study.
Fedirko V, et al. Am J Epidemiol. 2010 Sep 1;172(5):489-500. PMID: 20650953.

Megalin-mediated endocytosis of vitamin D binding protein correlates with 25-hydroxycholecalciferol actions in human mammary cells.
Rowling MJ, et al. J Nutr. 2006 Nov;136(11):2754-9. PMID: 17056796.

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Keywords: Calcifediol, Calcidiol supplier, Vitamin, inhibitors

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