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Vitamin C (L-Ascorbic Acid)

Cat. No. M3121
Vitamin C (L-Ascorbic Acid) Structure
Synonym:

Ascorbic acid

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
500mg USD 40  USD40 In stock
1g USD 52  USD52 In stock
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Quality Control & Documentation
Biological Activity

Vitamin C (L-Ascorbic Acid) is a water-soluble vitamin indicated for the prevention and treatment of scurvy.

Product Citations
Chemical Information
Molecular Weight 176.12
Formula C6H8O6
CAS Number 50-81-7
Solubility (25°C) Water 60 mg/mL
DMSO 50 mg/mL
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sungrae Cho, et al. Sci Rep. Hormetic dose response to L-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression

[2] Aleksander Hinek, et al. J Dermatol Sci. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin

[3] Michael T Nelson, et al. J Neurosci. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate

[4] Satyanarayana Sreemantula, et al. BMC Endocr Disord. Influence of antioxidant (L- ascorbic acid) on tolbutamide induced hypoglycaemia/antihyperglycaemia in normal and diabetic rats

[5] Sebastian J Padayatty, et al. J Am Coll Nutr. Vitamin C as an antioxidant: evaluation of its role in disease prevention

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