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Cholecalciferol

Cat. No. M5515
Cholecalciferol Structure
Synonym:

Vitamin D3; Colecalciferol

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 40  USD40 In stock
200mg USD 60  USD60 In stock
1g USD 100  USD100 In stock
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Quality Control & Documentation
Biological Activity

Vitamin D3 is a form of vitamin D, binds and activates a H305F/H397Y mutant vitamin D receptor (VDR) with EC50 of 300 nM.

*The compound is unstable in solutions, freshly prepared is recommended

Chemical Information
Molecular Weight 384.64
Formula C27H44O
CAS Number 67-97-0
Solubility (25°C) DMSO 40 mg/mL
Storage 2-8°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kidir V, et al. Ren Fail. Effect of cholecalciferol replacement on vascular calcification and left ventricular mass index in dialysis patients.

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Keywords: Cholecalciferol, Vitamin D3; Colecalciferol supplier, Vitamin, inhibitors, activators


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