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4-Quinazolinamine

Cat. No. M3238
4-Quinazolinamine Structure
Synonym:

4-Aminoquinazoline, NSC 288012

Size Price Availability
100mg USD 180  USD180 Out of stock
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Quality Control & Documentation
Biological Activity

4-Quinazolinamine (4-Aminoquinazoline) is a potent and highly selective EGFR tyrosine kinase inhibitor. 4-Quinazolinamine (4-Aminoquinazoline) is useful as a fungicide and as an anti-inflammatory, antimicrobial and antihypertensive agent. Besides, the derivatives of 4-Quinazolinamine (4-Aminoquinazoline) is a novel class of opioid receptor like-1 (ORL1) antagonists.

Chemical Information
Molecular Weight 145.16
Formula C8H7N3
CAS Number 15018-66-3
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] No authors listed. Vandetanib

[2] No authors listed. Lapatinib

[3] No authors listed. Gefitinib

[4] Joseph W Polli, et al. The role of efflux and uptake transporters in [N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (GW572016, lapatinib) disposition and drug interactions

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  Catalog
Abmole Inhibitor Catalog




Keywords: 4-Quinazolinamine, 4-Aminoquinazoline, NSC 288012 supplier, EGFR/HER2, inhibitors, activators


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