About 30 results found for searched term "KI-7" (0.028 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1739 | PKI-179 | PI3K |
| PKI-179 is an orally dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor with potential antineoplastic activity. | ||
| M1772 | PKI-587 | PI3K |
| Gedatolisib; PF-05212384 | ||
| PKI-587 (Gedatolisib; PF-05212384) is a highly potent dual PI3K/mTOR kinase inhibitor with the IC50 value of 0.4nM. | ||
| M1890 | SU11274 | c-Met |
| PKI-SU11274 | ||
| SU11274 is a selective c-Met inhibitor (IC50 = 0.01 μM in vitro). | ||
| M1913 | Neratinib | EGFR/HER2 |
| HKI-272 | ||
| Neratinib (HKI-272) is an orally available, irreversible inhibitor of Her 2 tyrosine kinase. | ||
| M1995 | Ki8751 | VEGFR/PDGFR |
| Ki8751 is a potent, selective inhibitor of VEGFR-2 tyrosine kinase (IC50 = 0.9 nM). | ||
| M2148 | RKI-1447 | ROCK |
| RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2 with IC50 of 14 nM and 6 nM, respectively. | ||
| M4871 | CL-387785 | EGFR/HER2 |
| EKI-785 | ||
| CL-387785 (EKI-785) is an irreversible, and selective EGFR inhibitor with IC50 of 370 pM. | ||
| M6865 | Ki 20227 | CSF-1R (c-Fms) |
| Ki 20227 is a c-Fms inhibitor; suppresses osteolysis and osteoclast accumulation. | ||
| M7351 | Talampanel | AMPK |
| GYKI-53773; LY-300164 | ||
| Talampanel is a non-competitive AMPA/kainate antagonist. | ||
| M7683 | CKI-7 dihydrochloride | Casein Kinase |
| CKI-7 is a CK1 inhibitor; also inhibits SGK, S6K1 and MSK1. | ||
| M9365 | Recombinant Human IL-7 Protein (CHO, C-Fc) | Cytokines and Growth Factors |
| Interleukin-7 | ||
| Recombinant Human IL-7 Protein (CHO, C-Fc) | ||
| M9910 | CDKI-73 | CDK |
| CDKI73; Asnuciclib; LS-007 | ||
| Cdki-73 (LS-007) is an orally active and highly effective CDK9 inhibitor with Ki values of 4 nM, 4 nM and 3 nM against CDK9, CDK1 and CDK2, respectively. Cdki-73 down-regulates phosphorylation of RNA polymerase II. Cdki-73 is also an inhibitor of Rab11. | ||
| M10139 | Anakinra | IL Receptor/Related |
| Raleukin; AMG-719 | ||
| Anakinra (Raleukin) is an antagonist of recombinant, nonglycosylated human IL-1R. | ||
| M11264 | KI-7 | Adenosine Receptor |
| Ki-7 is an A2B adenosine receptor positive allosteric regulator. Ki-7 enhances cAMP accumulation induced by NECA, a non-selective A2B adenosine receptor agonist (EC50=445.8 nM). Ki-7 also enhanced selective A2B adenosine receptor agonist BAY 60-6583 and adenosine-induced cAMP accumulation with EC50 of 2390 nM and 2550 nM, respectively. | ||
| M13356 | SKI-178 | SPHK |
| SKI-178 is a potent sphingosine kinase-1 (SphK1) and SphK2 inhibitor. In acute myeloid leukemia (AML) cell lines, the IC50 range is about 500 nm-1 μM. Ski-178 induces apoptosis of human acute myeloid leukemia cells in a CDK1-dependent manner. | ||
| M13730 | RKI-1447 dihydrochloride | ROCK |
| RKI 1447 dihydrochloride is a potent and selective ROCK inhibitor with IC50s of 14.5 and 6.2 nM for ROCK1 and ROCK2, respectively. RKI 1447 dihydrochloride suppresses colorectal carcinoma cell growth and promotes apoptosis. | ||
| M15040 | Recombinant Human MCP-3/CCL7 (CHO) | Cytokines and Growth Factors |
| C-C motif chemokine 7; Small inducible cytokine A7 | ||
| Chemokine (C-C Motif) Ligand 7 (CCL7) is a small cytokine formerly known as monocyte specific chemokine 3 (McP-3). | ||
| M20154 | WAY-348144 | Casein Kinase |
| Casein kinase 1δ-IN-7 | ||
| WAY-348144 is a Casein kinase 1δ inhibitor that can be used in studies related to neurodegenerative diseases such as Alzheimer's disease. | ||
| M21346 | Recombinant Human Cuteaneous T-cell Attracting Chemokine/CCL27 (E.coli ) | Cytokines and Growth Factors |
| AA Sequence：FLLPPSTACC TQLYRKPLSD KLLRKVIQVE LQEADGDCHL QAFVLHLAQR SICIHPQNPS LSQWFEHQER KLHGTLPKLN FGMLRKMG.Accession: Q9Y4X3. | ||
| M21402 | Recombinant Mouse IL-27 (HEK293, C-6His) | Cytokines and Growth Factors |
| Interleukin-27 subunit alpha; IL-27 subunit alpha | ||
| IL-27 is a heterodimeric cytokine which belongs to the IL-6/IL-12 family of long type I cytokines. Recombinant Mouse Interleukin-27 Subunit Alpha and Interleukin-27 Subunit Beta expressed the target gene encoding Tyr19-Pro228&Phe29-Ser234 with a 6His tag at the C-terminus. | ||
| M21556 | Recombinant Human IL-17A (E.coli) | Cytokines and Growth Factors |
| Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8 | ||
| Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. Recombinant human interleukin 17a is produced by the Escherichia coli expression system and expresses the target gene encoding Gly24-Ala155. | ||
| M21610 | Recombinant Mouse IL-7 (CHO, C-His) | Cytokines and Growth Factors |
| interleukin 7; IL7 | ||
| Recombinant Mouse IL-7 (Interleukin-7), also known as lymphopoietin 1 and pre-B cell factor, is a hematopoietic growth factor belonging to the IL-7/IL-9 family. It is produced by keratinocytes, dendritic cells, hepatocytes, neurons and epithelial cells. ED50 is < 0.4 ng/ml, measured in a cell proliferation assay using 2E8 cells. | ||
| M21705 | Recombinant Mouse IL-17F (HEK293, C-6His) | Cytokines and Growth Factors |
| Interleukin-17F | ||
| Recombinant Mouse Interleukin-17F is produced by Mammalian expression system and the target gene encoding Arg29-Ala161 is expressed with a 6His tag at the C-terminus. Interleukin-17F (IL-17F) exists in a disulfide-linked heterodimer that belongs to the IL-17 family. IL-17F is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. | ||
| M21706 | Recombinant Human IL-17F (HEK293, C-6His) | Cytokines and Growth Factors |
| Interleukin-17F human | ||
| Recombinant Human Interleukin-17F is produced by Mammalian expression system and the target gene encoding Arg31-Gln163 is expressed with a 6His tag at the C-terminus. IL-17F has been shown to stimulate the production of several other cytokines, including IL-6, IL-8, and granulocyte colony-stimulating factor. | ||
| M21723 | Recombinant Human IL-17F (HEK293) | Cytokines and Growth Factors |
| Interleukin-17F | ||
| Recombinant Human Interleukin-17F is produced by our Mammalian expression system and the target gene encoding Arg31-Gln163 is expressed. IL-17F can stimulate the production of several other cytokines, including IL-6, IL-8, and granulocyte colony-stimulating factor. IL-17F can regulate cartilage matrix turnover and stimulates PBMC and T-cell proliferation. The ED50 of Human IL-17F is 24.21 ng/ml. | ||
| M22476 | Exarafenib | Raf |
| KIN-2787 | ||
| Exarafenib (KIN-2787) is a highly selective, potent, next-generation, pan-RAF inhibitor with activity across BRAF and RAS mutant human tumor cell models. Exarafenib has anticancer activity by suppression of downstream MAPK pathway signaling. | ||
| M28818 | Cevidoplenib | Syk |
| SKI-O-703 | ||
| Cevidoplenib is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities. | ||
| M29035 | KIRA-7 | IRE1 |
| KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase (IC50 of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 has an anti-fibrotic effect. | ||
| M29129 | Cevidoplenib dimesylate | Syk |
| SKI-O-703 dimesylate | ||
| Cevidoplenib is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities. | ||
| M30896 | Neratinib maleate | EGFR/HER2 |
| HKI-272 maleate | ||
| Neratinib (HKI-272) maleate is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively. | ||
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