Free shipping on all orders over $ 500

PKI-179

Cat. No. M1739
PKI-179 Structure
Size Price Availability
5mg USD 180  USD180 Out of stock
10mg USD 280  USD280 Out of stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

PKI-179 is an orally dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor  with potential antineoplastic activity.

Chemical Information
Molecular Weight 488.54
Formula C25H28N8O3
CAS Number 1197160-28-3
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Venkatesan et al. Bioorg Med Chem Lett. PKI-179: an orally efficacious dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor.

[2] Chen et al. J Org Chem. Stereoselective synthesis of an active metabolite of the potent PI3 kinase inhibitor PKI-179.

Related PI3K Products
STX-478

STX-478 is a mutation-selective variant PI3Ka inhibitor for studies related to breast cancer and other solid tumors.

Hirsutenone

Hirsutenone is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone attenuates adipogenesis by binding directly to PI3K and ERK1 in a non-ATP competitive manner.

Boc-L-cyclobutylglycine

Boc-L-cyclobutylglycine is a glycine derivative that can be used for PI3K inhibitor synthesis.

PI-273 

PI-273 is a first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM. PI-273 can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis.

Chaetominine

Chaetominine is an alkaloidal metabolite. Chaetominine has cytotoxicity against human leukemia K562 and colon cancer SW1116 cell lines. Chaetominine reduces MRP1-mediated agent resistance via inhibiting PI3K/Akt/Nrf2 signaling pathway in K562/Adr human leukemia cells.

  Catalog
Abmole Inhibitor Catalog




Keywords: PKI-179 supplier, PI3K, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.