About 24 results found for searched term "PI3K" (0.04 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M5343 | Voxtalisib Analogue | PI3K |
| PI3K-IN-1; XL-147 derivative 1; SAR245409 | ||
| PI3K-IN-1 (XL-147 derivative 1) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2. | ||
| M10443 | Linperlisib (YY-20394) | PI3K |
| YY-20394; PI3Kδ-IN-2 | ||
| Linperlisib, also known as YY-20394 and PI3Kδ-IN-2, is a potent and selective PI3Kδ inhibitor. | ||
| M14854 | PI3K/mTOR Inhibitor-2 | PI3K |
| PI3K/mTOR Inhibitor-2 is a potent dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/34/16/1 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ and 4.7 nM for mTOR. Antitumor activity. | ||
| M20632 | Selective PI3Kδ Inhibitor 1 (compound 7n) | PI3K |
| Selective PI3Kδ Inhibitor 1 (compound 7n) is an inhibitor of PI3Kδ with an IC50 of 0.9 nM and >1000-fold selectivity against other class I PI3K isoforms [PI3K α/γ/β=3670/1460/21300 nM]. | ||
| M28008 | BEBT-908 | PI3K |
| PI3Kα inhibitor 1 | ||
| BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor with an IC50<0.1 μM, it also inhibits HDAC (0.1 μM≤IC50≤1 μM) . | ||
| M29360 | PI3K-IN-10 | PI3K |
| PI3K-IN-10 is a potent pan-PI3K inhibitor as a benzimidazole derivative. | ||
| M30007 | PI3K-IN-32 | PI3K |
| PI3K-IN-32 (compound 35) is a potent PI3K p110α inhibitor with an pIC50 of 6.85. | ||
| M43372 | PI3K-IN-48 | Akt |
| PI3K-IN-48 is a PI3K inhibitor with IC50 value of 1.55 ± 0.18 μM for A549 cells. | ||
| M43377 | PI3Kδ-IN-16 | Apoptosis |
| PI3Kδ-IN-16 is a potent and selective inhibitor of PI3Kδ. | ||
| M43388 | PI3Kγ inhibitor 7 | PI3K |
| PI3Kγ inhibitor 7 is a potent and orally active PI3Kγ inhibitor with IC50 values of 4768, 878.1, 3.42, 355.2 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, respectively. | ||
| M43390 | IHMT-PI3K-455 | PI3K |
| IHMT-PI3K-455 is a potent, selective, orally active PI3Kγ/δ dual inhibitor with IC50s of 7.1 nM and 0.57 nM for PI3Kγ and PI3Kδ, respectively. | ||
| M43391 | PI3K-IN-47 | PI3K |
| PI3K-IN-47 is a bivalent PI3K inhibitor (IC50: 0.44 nM for PI3Kα, 7.18 nM, 13.92 nM, 22.83 nM for PI3Kβ, PI3Kγ, PI3Kδ). | ||
| M43392 | PI3K-IN-41 | PI3K |
| PI3K-IN-41 is a photocaged compound, as well as a photocaged PI3K inhibitor (IC50=18.92 nM) with anticancer properties. | ||
| M43393 | PI3Kδ-IN-12 | PI3K |
| PI3Kδ-IN-12 is a PI3Kδ inhibitor (pIC50 = 5.8), with pKi values of 8.0/6.5/6.4/6.7 for PI3Kδ/γ/β/α, respectively. | ||
| M43398 | PI3Kδ-IN-14 | PI3K |
| PI3Kδ-IN-14 is a selective PI3Kδ inhibitor (IC50: 0.8 nM, Kd: 84.8 nM). | ||
| M43401 | PI3Kα-IN-13 | PI3K |
| PI3Kα-IN-13 is a PI3Kα inhibitor (IC50: 2.5 nM). | ||
| M43402 | PI3Kδ-IN-13 | PI3K |
| PI3Kδ-IN-13 is a PI3Kδ inhibitor (IC50=2.6 nM). | ||
| M55555 | PI3K/Akt/CREB activator 1 | PI3K |
| compound AE-18 | ||
| PI3K/Akt/CREB activator 1 (compound AE-18) is a potent, orally active PI3K/Akt/CREB activator. PI3K/Akt/CREB activator 1 promotes neuronal proliferation, induced differentiation of Neuro-2a cells into a neuron-like morphology, and accelerated the establishment of axon-dendrite polarization of primary hippocampal neurons through upregulating brain-derived neurotrophic factor via the PI3K/Akt/CREB pathway. | ||
| M57083 | PI3Kγ inhibitor AZ2 | PI3K |
| PI3Kγ inhibitor AZ2 is a highly selective PI3Kγ inhibitor (The pIC50 value for PI3Kγ is 9.3). | ||
| M57078 | PI3Kα-IN-22 | PI3K |
| PI3Kα-IN-22 is an orally active, potent and selective inhibitor of PI3KαH1047R, with an IC50 of 1 nM for pAKT T47D AlphaLISA. | ||
| M57077 | PI3K/AKT-IN-1 | PI3K |
| PI3K/AKT-IN-1 is an effective PI3K/AKT dual inhibitor (IC50 of 6.99, 4.01 and 3.36 μM for PI3Kγ, PI3Kδ and AKT, respectively). | ||
| M57076 | CHMFL-PI3KD-317 | PI3K |
| CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC50 of 6 nM, and exhibits over 10-1500 fold selectivity over other class I, II and III PIKK family isoforms. | ||
| M57075 | PI3Kδ-IN-1 | PI3K |
| PI3Kδ-IN-1 is a potent, selective, and efficacious PI3Kδ inhibitor with an IC50 of 1.7 nM. | ||
| M57074 | PI3K/Akt/mTOR-IN-2 | PI3K |
| PI3K/Akt/mTOR-IN-2 is a PI3K/AKT/mTOR pathway inhibitor. | ||
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