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Voxtalisib Analogue

Cat. No. M5343

All AbMole products are for research use only, cannot be used for human consumption.

Voxtalisib Analogue Structure
Synonym:

PI3K-IN-1; XL-147 derivative 1; SAR245409

Size Price Availability Quantity
2mg USD 50  USD50 In stock
5mg USD 85  USD85 In stock
10mg USD 150  USD150 In stock
25mg USD 260  USD260 In stock
50mg USD 400  USD400 In stock
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Quality Control & Documentation
Biological Activity

PI3K-IN-1 (XL-147 derivative 1) is a potent inhibitor of PI3K. PI3K-IN-1 (25 μM) blocks PI3K/Akt signaling pathways. By using the PI3K inhibitor PI3K-IN-1, TGF-β1 induced transformation into myofibroblast is also inhibited, with relatively reduced expressions of α-SMA, Col-1 and Timp-1.

Chemical Information
Molecular Weight 599.66
Formula C31H29N5O6S
CAS Number 1349796-36-6
Solubility (25°C) DMSO 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Awan FT, et al. Br J Haematol. Phase Ib trial of the PI3K/mTOR inhibitor voxtalisib (SAR245409) in combination with chemoimmunotherapy in patients with relapsed or refractory B-cell malignancies.

[2] Wen PY, et al. Neuro Oncol. Phase I dose-escalation study of the PI3K/mTOR inhibitor voxtalisib (SAR245409, XL765) plus temozolomide with or without radiotherapy in patients with high-grade glioma.

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  Catalog
Abmole Inhibitor Catalog




Keywords: Voxtalisib Analogue, PI3K-IN-1; XL-147 derivative 1; SAR245409 supplier, PI3K, inhibitors, activators

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