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Linperlisib (YY-20394)

Cat. No. M10443
Linperlisib (YY-20394) Structure
Synonym:

YY-20394; PI3Kδ-IN-2

Size Price Availability Quantity
10mg USD 150  USD150 In stock
25mg USD 300  USD300 In stock
50mg USD 450  USD450 In stock
100mg USD 700  USD700 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Linperlisib, also known as YY-20394 and PI3Kδ-IN-2, is a potent and selective PI3Kδ inhibitor. Linperlisib significantly inhibited T cell differentiation into Treg both in mouse splenocyte and in human primary CD4+ T cells, and was especially potent inhibiting their IL-10 secretion in vitro. YY-20394 significantly inhibited primary tumor growth in immune-competent mice with 4T1 and CT26 tumors, as well as 4T1 lung metastasis with dose dependency.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 588.69
Formula C28H37FN6O5S
CAS Number 1702816-75-8
Purity >99%
Solubility DMSO 50 mg/mL
Storage at -20°C
References

[1] Bo Jiang, et al. J Hematol Oncol. Ρhаse 1 cliпιcаl tгιal of the PI3Kδ inhibitor YY-20394 in ρаtιепts with B-cell hematological malignancies

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Linperlisib (YY-20394), YY-20394; PI3Kδ-IN-2 supplier, PI3K, inhibitors

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