All AbMole products are for research use only, cannot be used for human consumption.
IL-27 is a heterodimeric cytokine that belongs to the IL-6/IL-12 family of long-type type I cytokines. It is expressed on monocytes, endothelial cells and dendritic cells. IL-27 enhances the early phase of the TH1 response and inhibits the differentiation of TH2 and TH17. It induces TH1 cell differentiation through two distinct pathways, the p38 MAPK/TBX21 and the ICAM1/ITGAL/ERK-dependent pathways. It also induces phosphorylation of STAT1, STAT3, STAT4 and STAT5 and activates TBX21/T-Bet via STAT1, resulting in upregulation of IL12RB2, an event critical for TH1 cell commitment. IL-27 has anti-proliferative activity against melanoma via WSX-1/STAT1 signaling.
Accession O35228&Q8K3I6
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 50-65 KDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of PBS, 2mM EDTA, 5% Trehalose, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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Products are for research use only. Not for human use. We do not sell to patients.
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