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Exarafenib (KIN-2787) is a highly selective, potent, next-generation, pan-RAF inhibitor with activity across BRAF and RAS mutant human tumor cell models. Exarafenib has anticancer activity by suppression of downstream MAPK pathway signaling. KIN-2787 in combination with binimetinib demonstrated significant combination benefit in NRAS mutant melanoma models.
| Molecular Weight | 521.58 |
| Formula | C26H34F3N5O3 |
| CAS Number | 2639957-39-2 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
[3] Claus Garbe, et al. Recent Results Cancer Res. Vemurafenib
[5] Claus Garbe, et al. Recent Results Cancer Res. Vemurafenib
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