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CDKI-73

Cat. No. M9910
CDKI-73 Structure
Synonym:

CDKI73; Asnuciclib; LS-007

Size Price Availability Quantity
5mg USD 420  USD420 In stock
10mg USD 600  USD600 In stock
25mg USD 1100  USD1100 In stock
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Quality Control & Documentation
Biological Activity

Cdki-73 (LS-007) is an orally active and highly effective CDK9 inhibitor with Ki values of 4 nM, 4 nM and 3 nM against CDK9, CDK1 and CDK2, respectively. Cdki-73 down-regulates phosphorylation of RNA polymerase II. Cdki-73 is also an inhibitor of Rab11.

Chemical Information
Molecular Weight 394.45
Formula C15H15FN6O2S2
CAS Number 1421693-22-2
Solubility (25°C) DMSO 40 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Muhammed H Rahaman, et al. Invest New Drυgs. CDKI-73: an orally bioavailable and highly efficacious CDK9 inhibitor against acute myeloid leukemia

[2] Frankie Lam, et al. Oncotarget. Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73

[3] Elisabeth Walsby, et al. Oncotarget. A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine

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  Catalog
Abmole Inhibitor Catalog




Keywords: CDKI-73, CDKI73; Asnuciclib; LS-007 supplier, CDK, inhibitors, activators


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