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Recombinant Human IL-17A (E.coli)

Cat. No. M21556
Recombinant Human IL-17A (E.coli) Structure
Synonym:

Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8

Size Price Availability Quantity
10ug USD 130  USD130 In stock
50ug USD 280  USD280 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin<1 EU/µg
  • COA
  • MSDS
Biological Activity

Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and mice. Because IL-17 has the same properties as IL-1 and tnf-α, it may cause joint inflammation and bone and cartilage destruction. This cytokine is present in the synovial fluid of patients with rheumatoid arthritis and is produced by the synovial membrane of rheumatoid arthritis. It increases IL-6 production, induces collagen degradation, reduces collagen synthesis in synovium and cartilage, and proteoglycan synthesis in cartilage. IL-17 also increases bone destruction and reduces its formation. Blocking interleukin-17 with specific inhibitors provides protective inhibition of cartilage and bone degradation.

Measured by its ability to induce IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells, the ED50 for this effect is 1-7 ng/ml.


Accession Q16552

Endotoxin < 1 EU/µg

Apparent Molecular Weight: 16 KDa, reducing conditions

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in distilled water up to 100 μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jiong Zhang, et al. Int Immunopharmacol. HMGB1-TLR4-IL-23-IL-17A axis accelerates renal ischemia-reperfusion injury via the recruitment and migration of neutrophils

[2] Jessica E Miller, et al. Front Immunol. IL-17A Modulates Peritoneal Macrophage Recruitment and M2 Polarization in Endometriosis

[3] Lei Wang, et al. Thorax. Targeting IL-17 attenuates hypoxia-induced pulmonary hypertension through downregulation of β-catenin

[4] Jacob S Lee, et al. Immunity. Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability

[5] Dhavalkumar D Patel, et al. Ann Rheum Dis. Effect of IL-17A blockade with secukinumab in autoimmune diseases

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Keywords: Recombinant Human IL-17A (E.coli), Interleukin-17A; IL-17; IL-17A; Cytotoxic T-Lymphocyte-Associated Antigen 8 supplier, Recombinant Proteins, inhibitors, activators


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