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Recombinant Mouse IL-17F (HEK293, C-6His)

Cat. No. M21705

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Mouse IL-17F (HEK293, C-6His) Structure
Synonym:

Interleukin-17F

Size Price Availability Quantity
10ug USD 220  USD220 In stock
50ug USD 600  USD600 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Recombinant Mouse Interleukin-17F is produced by Mammalian expression system and the target gene encoding Arg29-Ala161 is expressed with a 6His tag at the C-terminus. Interleukin-17F (IL-17F) exists in a disulfide-linked heterodimer that belongs to the IL-17 family. IL-17F is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. IL-17F has been shown to stimulate the production of several other cytokines, including IL-6, IL-8, and granulocyte colony-stimulating factor. IL-17F can regulate cartilage matrix turnover and stimulates PBMC and T-cell proliferation. IL-17F is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1.

Accession: Q7TNI7

APMol Mass: 17-23 KDa, reducing conditions

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Chemical Information
Solubility (25°C) Dissolve the lyophilized protein in distilled water.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt
References

[1] Alexander O Mann, et al. J Exp Med. IL-17A-producing γδT cells promote muscle regeneration in a microbiota-dependent manner

[2] Jessica E Miller, et al. Front Immunol. IL-17A Modulates Peritoneal Macrophage Recruitment and M2 Polarization in Endometriosis

[3] Lei Wang, et al. Thorax. Targeting IL-17 attenuates hypoxia-induced pulmonary hypertension through downregulation of β-catenin

[4] Jacob S Lee, et al. Immunity. Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability

[5] Hye Young Kim, et al. Nat Med. Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity

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Keywords: Recombinant Mouse IL-17F (HEK293, C-6His), Interleukin-17F supplier, Cytokines and Growth Factors, inhibitors, activators

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