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Recombinant Mouse IL-7 (CHO, C-His)

Cat. No. M21610

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Mouse IL-7 (CHO, C-His) Structure
Synonym:

interleukin 7; IL7

Size Price Availability Quantity
10ug USD 200  USD200 In stock
50ug USD 750  USD750 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
  • Purity: >95%, Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
Biological Activity

Recombinant Mouse IL-7 (Interleukin-7), also known as lymphopoietin 1 and pre-B cell factor, is a hematopoietic growth factor belonging to the IL-7/IL-9 family. It is produced by keratinocytes, dendritic cells, hepatocytes, neurons and epithelial cells. IL-7 binds and signals through IL-7 receptor, a heterodimer consisting of IL-7 receptor alpha and common gamma chain receptor. IL-7 plays a role in regulating early B cell and T cell development.

Recombinant Mouse IL-7 expressed the target gene encoding Glu26-Ile154 with a His tag at the C-terminus.

ED50 < 0.4 ng/ml, measured in a cell proliferation assay using 2E8 cells.


Accession: Q544C8

Endotoxin < 0.2 EU/µg

Apparent Molecular Weight: 8~28kDa, reducing conditions

Lyophilized after extensive dialysis against PBS.

Customer Product Validations & Biological Datas
Source Customer Feedback
Method cell proliferation assay
Cell Lines 2E8 cells
Concentrations
Incubation Time
Results Measured in a cell proliferation assay using 2E8 cells, ED₅₀ is <0.4 ng/ml.
Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
References

[1] Miriam Y Kim, et al. Nat Commun. A long-acting interleukin-7, rhIL-7-hyFc, enhances CAR T cell expansion, persistence, and anti-tumor activity

[2] Jian L Campian, et al. Clin Cancer Res. Long-Acting Recombinant Human Interleukin-7, NT-I7, Increases Cytotoxic CD8 T Cells and Enhances Survival in Mouse Glioma Models

[3] Juan Huang, et al. Front Immunol. The Broad Immunomodulatory Effects of IL-7 and Its Application In Vaccines

[4] Hyein Jeong, et al. J Immunother Cancer. Recombinant Mycobacterium smegmatis delivering a fusion protein of human macrophage migration inhibitory factor (MIF) and IL-7 exerts an anticancer effect by inducing an immune response against MIF in a tumor-bearing mouse model

[5] Jifeng Zhu, et al. J Cell Mol Med. IL-7 suppresses macrophage autophagy and promotes liver pathology in Schistosoma japonicum-infected mice

[6] Yang Xu, et al. Blood. Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15

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Keywords: Recombinant Mouse IL-7 (CHO, C-His), interleukin 7; IL7 supplier, Cytokines and Growth Factors, inhibitors, activators

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