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KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase (IC50 of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 has an anti-fibrotic effect.
| Molecular Weight | 466.51 |
| Formula | C27H23FN6O |
| CAS Number | 1937235-76-1 |
| Form | Solid |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related IRE1 Products |
|---|
| BDM44768
BDM44768 is an inhibitior of IDE. |
| IRE1α kinase-IN-5
IRE1α kinase-IN-5 is a potent IRE1α inhibitor with an Ki of 98 nM. |
| Z4P
Z4P is a BBB-permeable IRE1 inhibitor (IC50: 1.11 μM). |
| IRE1α kinase-IN-9
IRE1α kinase-IN-9 is a potent IRE-1α inhibitor, exhibits an average IC50 value of <0.1 μM. |
| IRE1α kinase-IN-8
IRE1α kinase-IN-8, a benzoheterocyclecarboxaldehyde derivative, is a potent IRE-1α inhibitor. |
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