| Cat.No. | Name | Information |
|---|---|---|
| M8331 | STF-083010 | STF-083010 is a potent inhibitor of the ER transmembrane protein IRE1, which mediates the unfolded protein response. |
| M27898 | IXA4 | IXA4 is a highly selective, non-toxic IRE1/XBP1s activator. IXA4 activates IRE1/XBP1s signaling without globally activating the unfolded protein response (UPR) or other stress-responsive signaling pathways (e.g., the heat shock response or oxidative stress response). IXA4 reduces secretion of APP through IRE1 activation. |
| M13686 | MKC8866 | MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC50 of 0.29 μM in human vitro. |
| M13384 | Kira8 | Kira8 (AMG-18) is a single selective IRE1α inhibitor with an IC50 of 5.9 nM. |
| M10395 | MKC-3946 | MKC-3946 is a potent IRE1α inhibitor which triggered modest growth inhibition in multiple myeloma cell lines. |
| M9621 | KIRA6 | KIRA6 is a potent type II IRE1α kinase inhibitor with an IC50 of 0.6 µM. |
| M5283 | 4μ8C | 4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM. |
| M55995 | BDM44768 | BDM44768 is an inhibitior of IDE. |
| M55994 | IRE1α kinase-IN-5 | IRE1α kinase-IN-5 is a potent IRE1α inhibitor with an Ki of 98 nM. |
| M41517 | Z4P | Z4P is a BBB-permeable IRE1 inhibitor (IC50: 1.11 μM). |
| M41516 | IRE1α kinase-IN-9 | IRE1α kinase-IN-9 is a potent IRE-1α inhibitor, exhibits an average IC50 value of <0.1 μM. |
| M41515 | IRE1α kinase-IN-8 | IRE1α kinase-IN-8, a benzoheterocyclecarboxaldehyde derivative, is a potent IRE-1α inhibitor. |
| M29438 | Kira8 Hydrochloride | Kira8 Hydrochloride (AMG-18 Hydrochloride) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM. |
| M29035 | KIRA-7 | KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase (IC50 of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 has an anti-fibrotic effect. |
| M28661 | B I09 | B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM. |
| M13685 | GSK2850163 | GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC50s of 20 and 200 nM, respectively. |
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