All AbMole products are for research use only, cannot be used for human consumption.
STF-083010 is a potent inhibitor of the ER transmembrane protein IRE1, which mediates the unfolded protein response. STF-083010 inhibits IRE1 endonuclease and mRNA splicing activity in response to endopasmic reticulum (ER) stress, but has no affect on the kinase activity of IRE1.
J Leukoc Biol. 2024 May 15;qiae114.
Treponema pallidum recombinant protein Tp0768 enhances the ability of HUVECs to promote neutrophil chemotaxis through TLR2/ER stress signaling pathway
STF-083010 purchased from AbMole
Mol Microbiol. 2023 Jan;119(1):86-100.
Treponema pallidum lipoprotein Tp0768 promotes the migration and adhesion of THP-1 cells to vascular endothelial cells through stress of the endoplasmic reticulum and the NF-κB/HIF-1α pathway
STF-083010 purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | SKOV3 and OVCAR3 human ovarian cancer cells |
| Preparation method | SKOV3 and OVCAR3 cells (5 × 10^5 cells in each well) were seeded into a six-well plate and treated with various ranges of STF-083010 (0.1, 1, 10, and 50 μmol/L) in the presence of Tm (3 μg/ml) for 18 h. After treatment, caspase-12 and caspase-3 activity were detected according to the manufacturer’s instructions. STF-083010 stock solution was prepared by dissolving powder in DMSO, and vehicle control cells were incubated with equal volume DMSO under identical culture conditions. |
| Concentrations | 0.1, 1, 10, 50 μM |
| Incubation time | 18 h |
| Animal Experiment | |
|---|---|
| Animal models | NOD/SCID/IL2Rγ null mice bearing RPMI 8226 human multiple myeloma subcutaneous xenograft tumors |
| Formulation | STF-083010 was dissolved in DMSO and further diluted with 16% cremophor for intraperitoneal injection. |
| Dosages | 30 mg/kg body weight |
| Administration | When tumors reached an average volume of 150 mm³, mice received intraperitoneal injection of STF-083010 once weekly for 2 consecutive weeks; control mice were injected with equal volume vehicle solution following the same schedule. |
| Molecular Weight | 317.38 |
| Formula | C15H11NO3S2 |
| CAS Number | 307543-71-1 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related IRE1 Products |
|---|
| APY29
APY29, an ATP-competitive inhibitor, is an allosteric modulator of IRE1α which inhibits IRE1α autophosphorylation by binding to the ATP-binding pocket with IC50 of 280 nM. |
| 4μ8C
4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM. |
| KIRA6
KIRA6 is a potent type II IRE1α kinase inhibitor with an IC50 of 0.6 µM. |
| MKC-3946
MKC-3946 is a potent IRE1α inhibitor which triggered modest growth inhibition in multiple myeloma cell lines. |
| Kira8
Kira8 (AMG-18) is a single selective IRE1α inhibitor with an IC50 of 5.9 nM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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