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Kira8 Hydrochloride (AMG-18 Hydrochloride) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.
| Molecular Weight | 637.58 |
| Formula | C31H30Cl2N6O3S |
| CAS Number | 2250019-92-0 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Related IRE1 Products |
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| APY29
APY29, an ATP-competitive inhibitor, is an allosteric modulator of IRE1α which inhibits IRE1α autophosphorylation by binding to the ATP-binding pocket with IC50 of 280 nM. |
| 4μ8C
4μ8C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM. |
| STF-083010
STF-083010 is a specific IRE1α inhibitor. STF-083010 inhibits Ire1 endonuclease activity, without affecting its kinase activity, after endoplasmic reticulum stress. STF-083010 is a potent inhibitor of the ER transmembrane protein IRE1, which mediates the unfolded protein response. |
| KIRA6
KIRA6 is a potent type II IRE1α kinase inhibitor with an IC50 of 0.6 µM. |
| MKC-3946
MKC-3946 is a potent IRE1α inhibitor which triggered modest growth inhibition in multiple myeloma cell lines. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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