About 31 results found for searched term "Enzyme-IN-2" (0.083 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M41071 | Enzyme-IN-2 | Antibiotic |
| Enzyme-IN-2 is a ureases inhibitor (Ki=2.36 μM) with anti-ureolytic activity (IC50=0.75 μM). | ||
| M1861 | Silmitasertib (CX-4945) | Casein Kinase |
| Silmitasertib; CX-4945 | ||
| CX-4945 (Silmitasertib) is a potent small molecule protein kinase inhibitor that selectively binds to and inhibits the enzyme casein kinase II (CK2). | ||
| M2565 | PR-619 | Deubiquitinase |
| 2,6-Diamino-3,5-dithiocyanopyridine | ||
| PR-619 is a broad-spectrum reversible DUB (deubiquitinating enzyme) inhibitor of USP2, USP4, USP5, USP7 and USP8 with an EC50 of 3-9 μM. PR-619 also induces endoplasmic reticulum stress and endoplasmic reticulum stress-associated apoptosis. | ||
| M2690 | Ethoxzolamide | Carbonic Anhydrase |
| Redupresin; L-643786; PNU-4191 | ||
| Ethoxzolamide is an inhibitor of the metalloenzyme carbonic anhydrase, which inhibits hCA I, hCA II, hCA IV, hCA VI and hCA VII with Ki of 25 nM, 8 nM, 93 nM, 43 nM and 0.8 nM, respectively. | ||
| M3477 | Imidapril hydrochloride | ACE |
| TA-6366 | ||
| Imidapril hydrochloride is a angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension. | ||
| M3612 | Quinapril hydrochloride | ACE |
| Quinapril hydrochloride is the hydrochloride salt of quinapril that is an angiotensin-converting enzyme inhibitor with a Ki of 20 μM. | ||
| M4256 | Gomisin-J | AMPK |
| Gomisin J isa small molecular weight lignan found in Schisandra chinensis with vasodilatory activity. Gomisin J regulates lipogenesis, lipolytic enzyme and inflammatory molecule expression to inhibit lipid accumulation by activating AMPK, LKB1 and Ca2+/ Calmodulin-dependent protein kinase II and inhibiting Fetuin-A in HepG2 cells. Gomisin J has potential benefits in the study of non-alcoholic fatty liver disease. | ||
| M4573 | Diosmetin | Cytochrome P450 (e.g. CYP17) |
| Diosmetin is a natural flavonoid that inhibits the activity of human CYP1A enzyme. The IC50 value of Diosmetin in HepG2 cells is 40 μM. | ||
| M4846 | CC0651 | E1/E2/E3 Enzyme |
| CC 0651, CC-0651 | ||
| CC0651 is an allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme and inhibited the ubiquitination of p27Kip1 with IC50 value of 1.72 μM. | ||
| M4945 | Enasidenib | Isocitrate Dehydrogenase (IDH) |
| AG-221 | ||
| Enasidenib is an oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes, with IC50s of 100 and 400 nM against IDH2R140Q and IDH2R172K, respectively. | ||
| M4951 | d-Alaninol | Others |
| Coenzyme B(12)-dependent ethanolamine ammonia-lyase acts on both enantiomers of the substrate 2-amino-1-propanol. | ||
| M5482 | CB1954 | Others |
| Tretazicar | ||
| CB1954(Tretazicar) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2. | ||
| M6216 | TAPI-2 | MMP |
| TAPI-2 is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20±10 μM for MMP. | ||
| M6240 | Angiotensin II human | Animal Modeling |
| Angiotensin II; Hypertensin II; Ang II; DRVYIHPF | ||
| Angiotensin II human is converted by Angiotensin I through removal of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE). Angiotensin II is mediated by AT1 and AT2 receptors, which are seven transmembrane glycoproteins with 30% sequence similarity. Keep away from light and prepare for use now. | ||
| M7500 | YK 3-237 | Sirtuin |
| YK 3-237 is a boronic acid chalcone analog of combretastatin a4 (CA-4) and a SIRT1 activator that targets mutant p53. YK 3-237 can reduce the acetylation of mutant p53 protein by activating the SIRT1 enzyme, resulting in a significant decrease in the level of mutant p53 protein. YK-3-237 showed antiproliferative activity against tumor cells containing mutant p53 protein. | ||
| M7790 | Emodin | Casein Kinase |
| Frangula emodin | ||
| Emodin is an anti-SARS-CoV compound that blocks the interaction between the SARS-coronavirus spike protein and angiotensin converting enzyme 2 (ACE2). Emodin inhibited casein kinase 2 (CK2) and 11β-HSD1. Emodin can also induce necrotic apoptosis of glioma U251 cells and inhibit U251 cell proliferation by targeting the TNF/RIPK1/RIPK3 signaling pathway. | ||
| M8473 | RA-9 | Others |
| RA-9 is a cell permeable and potent inhibitor of the ubiquitin-proteasome system (UPS) that targets deubiquitinating enzymes (DUB) without affecting 20S proteasome catalytic-core activity. | ||
| M8773 | Liarozole dihydrochloride | Others |
| Liarozole (R 75251, R75,251) is an orally active benzimidazole-based retinoic acid (RA) metabolism blocking agent (RAMBA) that targets multiple P450 enzymes, including aromatase (CYP19), 17-hydroxylase/17,20-lyas |
||
| M9735 | ND-646 | Others |
| ND646 | ||
| ND-646 is an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 with IC50 values of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively. | ||
| M9871 | GSK2643943A | Deubiquitinase |
| GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor targeting USP20/Ub-Rho with an IC50 of 160 nM. GSK2643943A has anti-tumor efficacy and can be used for the research of oral squamous cell carcinoma (OSCC). | ||
| M10275 | Bobcat339 | DNA Methyltransferase |
| Bobcat-339 | ||
| Bobcat339 is a novel cytosine-based TET enzyme inhibitor with IC50s of 33 and 73 uM for TET1/2, it does not inhibit the DNA methyltransferase DNMT3a. | ||
| M11376 | 2,4-Diamino-6-hydroxypyrimidine | NO Synthase |
| DAHP | ||
| 2, 4-diamino-6-hydroxypyrimidine is a specific inhibitor of GTP cyclohydrolase I, a rate-limiting enzyme involved in de novo protein synthesis. 2, 4-diamino-6-hydroxypyrimidine can block the synthesis of Tetrahydrobiopterin (BH4) and inhibit the production of NO. | ||
| M13627 | DUB-IN-3 | Deubiquitinase |
| DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c with an IC50 of 0.56 μM for USP8. | ||
| M13685 | GSK2850163 | IRE1 |
| GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC50s of 20 and 200 nM, respectively. | ||
| M14300 | MLN-4760 | ACE |
| MLN-4760 is a potent and selective human ACE2 inhibitor (IC50, 0.44 nM), with excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA; IC50, 27 μM). | ||
| M14331 | TZ9 | E1/E2/E3 Enzyme |
| TZ9 is a novel inhibitor of Rad6 ubiquitin conjugating enzyme(E2 enzyme); inhibits MDA-MB-231 cell proliferation with IC50 of ~6 uM. | ||
| M14493 | MSI-1436 lactate | Phosphatase |
| Trodusquemine lactate; Aminosterol-1436 lactate | ||
| MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B), with an IC50 of 1 μM, 200-fold preference over TCPTP (IC50 of 224 μM). | ||
| M15018 | Recombinant Human ACE-2 (HEK293,C-6His) | Cytokines and Growth Factors |
| Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase | ||
| Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. | ||
| M17603 | Cedrol | Cytochrome P450 (e.g. CYP17) |
| Cedrol is a potent competitive inhibitor of cytochrome P-450 (CYP) enzymes. Cedrol inhibits CYP2B6-mediated bupropion hydroxylase and CYP3A4-mediated midazolam hydroxylation with Ki of 0.9 μM and 3.4 μM, respectively. Cedrol also has weak inhibitory effect on CYP2C8, CYP2C9, and CYP2C19 enzymes. | ||
| M19263 | Adenanthin | NF-κB |
| ADE | ||
| Adenanthin is an inhibitor of thiol-dependent antioxidant enzymes, targeting to Prx 1 and Prx 2. Adenanthin inhibits NF-κB signaling and lipogenesis and the development of obesity by regulating ROS. | ||
| M19993 | Recombinant Human B4GALT1 (HEK293, C-6His) | Cytokines and Growth Factors |
| 1,4- galactosyltransferase, polypeptide 1; B4GalT1 | ||
| Beta1,4-Galactosyltransferase-I (B4GALT1) is an enzyme commonly found in the trans-Golgi complex that adds galactose to oligosaccharides. Accession: P15291. | ||
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