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Imidapril hydrochloride

Cat. No. M3477
Imidapril hydrochloride Structure
Synonym:

TA-6366

Size Price Availability Quantity
50mg USD 180  USD180 In stock
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Quality Control & Documentation
Biological Activity

Imidapril hydrochloride is a angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension.

Chemical Information
Molecular Weight 441.91
Formula C20H27N3O6.HCl
CAS Number 89396-94-1
Solubility (25°C) DMSO 80 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xue-Qin Hao, et al. Imidapril inhibits right ventricular remodeling induced by low ambient temperature in broiler chickens

[2] Tomas Dolezal. Imidapril in heart failure

[3] Hiroshi Satonaka, et al. Long-term effect of imidapril hydrochloride compared with dilazep hydrochloride administration on blood pressure and renal function in patients with chronic glomerulonephritis

[4] Ji Hye Yun, et al. LC-MS determination and bioavailability study of imidapril hydrochloride after the oral administration of imidapril tablets in human volunteers

[5] Kazuyoshi Hosoya, et al. Protection of the cardiovascular system by imidapril, a versatile angiotensin-converting enzyme inhibitor

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