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Imidapril hydrochloride is a angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension. Imidapril hydrochloride inhibits lipopolysaccharide-induced phosphorylation of c-Jun, MKK4 and JNK in monocytes, and downregulates the production of specific inflammatory factors such as TNF-α and IP-10, thereby exerting anti-inflammatory activity.
| Molecular Weight | 441.91 |
| Formula | C20H27N3O6.HCl |
| CAS Number | 89396-94-1 |
| Solubility (25°C) | Water 45 mg/mL DMSO 45 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related ACE Products |
|---|
| Temocapril
Temocapril is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension. |
| Enalaprilat Dihydrate
Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM. |
| Ramipril
Ramipril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 5 nM. |
| Enalapril Maleate
Enalapril Maleate, the active metabolite of enalapril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. |
| Perindopril Erbumine
Perindopril Erbumine is a potent ACE inhibitor with IC50 of 1.05 nM. |
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