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Zofenopril is a long-lasting, lipophilic ACE inhibitor with cardioprotective properties indicated for the treatment of hypertension. Zofenopril is also an inhibitor of PEPT2, the predominant peptide transporter in kidney and choroid plexus. zofenopril increases SR calcium cycling and stimulates active calcium uptake into the SR. In small studies, zofenopril appeared significantly more effective than the older antihypertensives atenolol and enalapril, and was associated with fewer adverse effects.
| Molecular Weight | 428.54 |
| Formula | C22H22NO4S2 |
| CAS Number | 81938-43-4 |
| Solubility (25°C) | DMSO ≥ 1 mg/mL (Need ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related ACE Products |
|---|
| Enalaprilat
Enalaprilat (MK-422 anhydrous), the active metabolite of the oral proagent Enalapril, is a potent, competitive and long-acting angiotensin-converting enzyme (ACE) inhibitor, with an IC50 of 1.94 nM. |
| Deserpidine
Deserpidine (Harmonyl) is an alkaloid isolated from the root of Rauwolfia canescens related to Reserpine. |
| H-Ile-Pro-Pro-OH hydrochloride
H-Ile-Pro-Pro-OH hydrochloride, a milk-derived peptide, inhibits angiotensin-converting enzyme (ACE) with an IC50 of 5 μM. |
| N-Benzoyl-Gly-His-Leu hydrate
N-Benzoyl-Gly-His-Leu hydrate is a leucine derivative, a polypeptide. |
| Bradykinin potentiator B
Bradykinin potentiator B (Bradykinin potentiating peptide B) is venom of Agkistrodon halys blomhoffi. |
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