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Perindopril Erbumine

Cat. No. M3610
Perindopril Erbumine Structure


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100mg USD 75  USD75 In stock
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Quality Control & Documentation
Biological Activity

Perindopril Erbumine (Aceon) is the tert-butylamine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor.

Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Incubation time
Animal Experiment
Animal models Female BALB/c nude mice injected with SCC-VII cells
Formulation Dissolved in DMSO, and diluted in saline
Dosages 1 or 2 mg/kg/day
Administration Orally
Chemical Information
Molecular Weight 441.6
Formula C19H32N2O5.C4H11N
CAS Number 107133-36-8
Form Solid
Solubility (25°C) Water 80 mg/mL
Ethanol 80 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] William J Elliott, et al. Perindopril arginine and amlodipine besylate for hypertension: a safety evaluation

[2] Matt Shirley, et al. Perindopril/amlodipine (Prestalia(®)): a review in hypertension

[3] James J Dinicolantonio, et al. Not all angiotensin-converting enzyme inhibitors are equal: focus on ramipril and perindopril

[4] John G F Cleland, et al. The perindopril in elderly people with chronic heart failure (PEP-CHF) study

[5] No authors listed. Am J Health Syst Pharm. Perindopril erbumine

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Abmole Inhibitor Catalog

Keywords: Perindopril Erbumine, S9490-3 supplier, ACE, inhibitors, activators

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