Free shipping on all orders over $ 500
Bobcat339 is a novel cytosine-based TET enzyme inhibitor with IC50s of 33 and 73 uM for TET1/2, it does not inhibit the DNA methyltransferase DNMT3a. Bobcat339 (10 μM in 1% DMSO) treated 24 hrs significantly reduces global 5hmC levels by inhibiting TET enzyme function in HT-22 cells.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 297.74 |
| Formula | C16H12ClN3O |
| CAS Number | 2280037-51-4 |
| Purity | 99.84% |
| Solubility | DMSO |
| Storage | at -20°C |
[1] Gabriella N L Chua, et al. ACS Med Chem Lett. Cytosine-Based TET Enzyme Inhibitors
| Related DNA Methyltransferase Products |
|---|
| GSK3685032
GSK3685032 is a potent first-in-class DNMT1-selective inhibitor. |
| DC_05
DC_05 is a potent and selective non-nucleoside DNMT1 (DNA methyltransferase 1) inhibitor that significantly inhibits cancer cell proliferation. |
| Vitamin D2
Vitamin D2 is a selective inhibitor of mammalian DNA polymerase A (pol A) with IC50 of 123 mM. |
| SGI-1027
SGI-1027 is a DNMT inhibitor with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B |
| RG108
RG108 is a novel small-molecule inhibitors of DNA methyltransferases with IC50 of 115 nM. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.
