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Bobcat339

Cat. No. M10275
Bobcat339 Structure
Synonym:

Bobcat-339

Size Price Availability Quantity
5mg USD 267  USD267 In stock
10mg USD 375  USD375 In stock
50mg USD 975  USD975 In stock
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Quality Control & Documentation
Biological Activity

Bobcat339 is a novel cytosine-based TET enzyme inhibitor with IC50s of 33 and 73 uM for TET1/2, it does not inhibit the DNA methyltransferase DNMT3a. Bobcat339 (10 μM in 1% DMSO) treated 24 hrs significantly reduces global 5hmC levels by inhibiting TET enzyme function in HT-22 cells.

Chemical Information
Molecular Weight 297.74
Formula C16H12ClN3O
CAS Number 2280037-51-4
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Gabriella N L Chua, et al. ACS Med Chem Lett. Cytosine-Based TET Enzyme Inhibitors

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Keywords: Bobcat339, Bobcat-339 supplier, DNA Methyltransferase, inhibitors, activators


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