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Bobcat339

Cat. No. M10275
Bobcat339 Structure
Synonym:

Bobcat-339

Size Price Availability Quantity
5mg USD 267  USD267 In stock
10mg USD 375  USD375 In stock
50mg USD 975  USD975 In stock
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Quality Control
Biological Activity

Bobcat339 is a novel cytosine-based TET enzyme inhibitor with IC50s of 33 and 73 uM for TET1/2, it does not inhibit the DNA methyltransferase DNMT3a. Bobcat339 (10 μM in 1% DMSO) treated 24 hrs significantly reduces global 5hmC levels by inhibiting TET enzyme function in HT-22 cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 297.74
Formula C16H12ClN3O
CAS Number 2280037-51-4
Purity 99.84%
Solubility DMSO
Storage at -20°C
References

[1] Gabriella N L Chua, et al. ACS Med Chem Lett. Cytosine-Based TET Enzyme Inhibitors

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Keywords: Bobcat339, Bobcat-339 supplier, DNA Methyltransferase, inhibitors

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