About 30 results found for searched term "C-82" (0.013 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1710 | Flavopiridol | CDK |
| HMR-1275; Alvocidib; L86-8275 | ||
| Flavopiridol (Alvocidib) is a competitive broad-spectrum CDK inhibitor with IC50 of 30,170,100 nM against CDK1, CDK2 and CDK4, respectively. | ||
| M1786 | Ispinesib | Kinesin |
| SB-715992, CK0238273 | ||
| Ispinesib (SB 715992) is the first potent, highly specific small-molecule inhibitor of kinesin spindle protein (KSP) with an IC50 of 4.1 nM. | ||
| M1966 | Fulvestrant | Estrogen Receptor |
| ICI 182780; ZD 9238; ZM 182780 | ||
| Fulvestrant is a Estrogen receptor (ER) antagonist with IC50 of 0.094 nM. Fulvestrant can also induce autophagy and apoptosis, and has anti-tumor effect. | ||
| M2004 | Omecamtiv mecarbil | Myosin |
| CK-1827452 | ||
| Omecamtiv Mecarbil is a First-In-Class selective small molecule cardiac myosin activator that directly targets the contractile machinery of the heart, binding and increasing the number of cardiac myosin head regions interacting with actin during contraction. | ||
| M2028 | Fludarabine | STAT |
| Fludara; NSC 118218; Fludarabinum; F-ara-A | ||
| Fludarabine (NSC 118218) is a STAT1 activation inhibitor and a DNA synthesis inhibitor. Fludarabine inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase. Fludarabine markedly inhibited VSMC proliferation in cell culture. Fludarabine also induces significant reduction of STAT-1 phosphorylation, whereas it does not change JAK2 activation. Fludarabine exhibits antiproliferative activity (IC50 = 1.54 μM in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. | ||
| M2107 | Calcium levofolinate | Others |
| Levoleucovorin Calcium; CL307782 | ||
| Calcium levofolinate is a calcium salt of folinic acid that is an adjuvant used in cancer chemotherapy. | ||
| M2858 | ML167 | CDK |
| CID 44968231 | ||
| ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B. | ||
| M3379 | Trifluridine | DNA/RNA Synthesis |
| Trifluridine; FTD; 5-Trifluorothymidine; NSC 529182; NSC 75520 | ||
| Trifluridine (Trifluorothymidine) is an irreversible and orally active thymidylate synthase inhibitor, and thereby suppressing DNA synthesis. Trifluridine is an antiviral molecule used for research of HSV, rhabdovirus and orthopoxvirus infection. | ||
| M3483 | Flavopiridol hydrochloride | CDK |
| NSC 649890 HCl; Alvocidib hydrochloride; L86 8275 HCl; HMR-1275 HCl | ||
| Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. | ||
| M3499 | Ezetimibe | Autophagy |
| SCH 58235 | ||
| Ezetimibe (Zetia) is a beta-lactam analog that targets NPC1L1, thereby lowering blood cholesterol levels. In addition, Ezetimibe can prevent spinal cord injury by inhibiting apoptosis through activation of autophagy and modulation of the PI3K/AKT/mTOR signaling pathway, which can be used in studies related to spinal cord injury. | ||
| M3749 | Pentostatin | Adenosine Deaminase |
| Deoxycoformycin; CI-825 | ||
| Pentostatin (Deoxycoformycin) is an irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM). | ||
| M4578 | Oridonin | NLR |
| Isodonol；NSC-250682 | ||
| Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Oridonin (NSC-250682) also acts as an inhibitor of AKT, with IC50 values of 8.4 and 8.9 μM for AKT1 and AKT2, respectively. | ||
| M4665 | Sarsasapogenin | Others |
| CAS# 82597-74-8 | ||
| Sarsasapogenin is a steroidal saponin element isolated from the Chinese herb Zhi Mu (知母), which possesses a wide range of activities such as antidiabetic, antioxidant, anticancer, and anti-inflammatory. | ||
| M4796 | Veratramine | Others |
| NSC17821; NSC23880 | ||
| Veratramine(NSC17821; NSC23880) is a signal transduction inhibitor that acts on tumors. | ||
| M4798 | Tunicamycin | Transferase |
| NSC 177382, TN | ||
| Tunicamycin is a mixture of nucleoside antibiotics that inhibits N-glycosylation and blocks GlcNAc phosphotransferase (GPT). | ||
| M4878 | Fludarabine Phosphate | DNA/RNA Synthesis |
| NSC 118218 phosphate | ||
| Fludarabine phosphate is an analogue of adenosine and deoxyadenosine, it competes with dATP for incorporation into DNA and inhibits DNA synthesis. | ||
| M4991 | Dihydroartemisinin | Parasite |
| β-Dihydroartemisinin; DHA; Artenimol; CAS# 81496-82-4 | ||
| Dihydroartemisinin is a potent anti-malaria agent. Dihydroartemisinin, a derivative of artemisinin in which the C-10 lactone group is replaced by hemiacetals and active metabolites of all artemisinin compounds, is a widely used antimalarial compound that effectively induces iron death in acute myeloid leukemia cells (HL60, KG1, and THP-1) by regulating iron metabolism. | ||
| M5116 | Formoterol Hemifumarate | Adrenergic Receptor |
| Eformoterol, CGP 25827A, NSC 299587, YM 08316 | ||
| Formoterol Hemifumarate is a potent, selective and long-acting β2-adrenoceptor agonist used in the management of asthma and chronic obstructive pulmonary disease. | ||
| M5447 | Benazepril hydrochloride | ACE |
| CGS 14824A HCl | ||
| Benazepril hydrochloride is an angiotensin converting enzyme (ACE) inhibitor. | ||
| M5639 | Fenbufen | COX |
| Lederfen, CL-82204 | ||
| Fenbufen is an orally active phenylalkanoic derivative with anti-inflammatory, analgesic and antipyretic activity. It is a non-steroidal anti-inflammatory drug. | ||
| M6405 | ACT 335827 | Others |
| ACT 335827 is a potent and selective OX 1 antagonist. | ||
| M6614 | CL 82198 hydrochloride | MMP |
| CL 82198 hydrochloride is a selective inhibitor of MMP-13. | ||
| M6906 | Levcromakalim | Potassium Channel |
| (-)-Cromakalim; BRL 38227 | ||
| Levcromakalim is a k ir6 (K ATP) channel opener; active enantiomer of cromakalim. | ||
| M7062 | NTRC 824 | Others |
| NTRC 824 is a potent and selective non-peptide NTS 2 antagonist. | ||
| M7282 | SCH 58261 | Adenosine Receptor |
| SCH58261 | ||
| SCH 58261 is a potent, highly selective A2A antagonist. | ||
| M7736 | CL-82198 | MMP |
| CL-82198 is a selective inhibitor of MMP-13 that displays no activity at MMP-1, MMP-9 or TACE. | ||
| M8901 | CHS-828 | NAMPT |
| GMX1778 | ||
| CHS-828 (GMX1778) is a potent and specific inhibitor of NAMPT with IC50 and Kd value of <25 nM and 120 nM, respectively. | ||
| M9596 | Pemigatinib | FGFR |
| INCB054828 | ||
| Pemigatinib (INCB054828) is an orally effective, selective FGFR inhibitor with IC50 values of 0.4 nM, 0.5 nM, 1.2 nM, and 30 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.Pemigatinib exhibited anti-tumor activity in mouse xenograft models with FGFR1, FGFR2, or FGFR3-altered human tumors in a mouse xenograft model exhibiting antitumor activity. | ||
| M9786 | Nimustine hydrochloride | DNA/RNA Synthesis |
| NSC-245,382 | ||
| Nimustine hydrochloride (ACNU) is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks. | ||
| M9904 | ODN 1826 | TLR |
| ODN1826; CpG 1826 | ||
| ODN 1826 is a class B CpG ODN and an agonist of TLR9, which promotes apoptosis and has antitumor activity. In addition, ODN 1826 induces NO and iNOS production in a mouse model. | ||
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