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ACT 335827 is a potent and selective orexin OX1 receptor antagonist (Kb values are 41 and 560 nM for OX1 and OX2 receptors respectively). Elicits anxiolytic effects in vivo. Brain penetrant and orally available.
| Molecular Weight | 518.64 |
| Formula | C31H38N2O5 |
| CAS Number | 1354039-86-3 |
| Solubility (25°C) | DMSO 51.86 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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