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Fludarabine phosphate is an analogue of adenosine and deoxyadenosine, it competes with dATP for incorporation into DNA and inhibits DNA synthesis. Fludarabine phosphate causes a significant decrease in cell viability for 24 h after exposure to ACE-PNP when compared to PBS and ACE-GFP at concentrations of 2.5, 5 and 10 μg/mL.
In vivo, Fludarabine (100 mg/kg given 15 times, 167 mg/kg given 9 times, or 250 mg/kg given 3 times, i.p.) leads to complete regressions of all tumors and cures of all mice.
| Molecular Weight | 365.21 |
| Formula | C10H13FN5O7P |
| CAS Number | 75607-67-9 |
| Solubility (25°C) | DMSO 80 mg/mL Water 5 mg/mL (Need ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Mikhailopulo IA,et.al. Acta Naturae. New trends in nucleoside biotechnology.
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