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Omecamtiv mecarbil, previously codenamed CK-1827452, is an agent that directly activates myosin, for use in the treatment of heart failure. Omecamtiv mecarbil specifically targets and activates myocardial ATPase and improves energy utilization. This enhances effective myosin cross-bridge formation and duration, while the velocity of contraction remains the same. Omecamtiv mecarbil also increases the rate of phosphate release from myosin, thereby accelerating the rate-determining step of the cross-bridge cycle, which is the transition of the actin-myosin complex from the weakly bound to the strongly bound state. Omecamtiv mecarbil could safely improve cardiac function within tolerated doses. Omecamtiv mecarbil is currently in Phase II clinical trials.
J Clin Invest. 2024 Jun 17;134(12):e177172.
Frameshift variants in C10orf71 cause dilated cardiomyopathy in human, mouse, and organoid models
Omecamtiv mecarbil purchased from AbMole
| Molecular Weight | 401.43 |
| Formula | C20H24FN5O3 |
| CAS Number | 873697-71-3 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Myosin Products |
|---|
| Ulacamten
Ulacamten is a potent cardiac myosin inhibitor. |
| Myosin Light Chain Kinase Substrate (smooth muscle)
Myosin Light Chain Kinase Substrate (smooth muscle) is a smooth muscle myosin light chain kinase (MLCK) synthetic peptide substrate. |
| Kemptamide
Kemptamide, a 13 amino acid fragment with a sequence corresponding to residues 11-23 of gizzard light chain. |
| MYK-224
MYK-224 is a cardiac myosin complex modulator that can be used in studies related to cardiovascular disease. |
| Myosin V-IN-1
Myosin V-IN-1 is a potent and selective Myosin V inhibitor, with a Ki of 6 μM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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