| Cat.No. | Name | Information |
|---|---|---|
| M9636 | Blebbistain | (±)-Blebbistatin (BLEB) is a small cell permeable selective myosin II inhibitor which potently relaxed normal detrusor smooth muscle. |
| M2459 | (-)-Blebbistatin | (-)-Blebbistatin is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. *The compound is unstable in solutions, freshly prepared is recommended |
| M40571 | 16-38-Thymosin β4 (cattle) TFA | 16-38-Thymosin β4 (cattle) TFA is a non-Ca2+-dependent MLCK activator with high affinity. |
| M21004 | Danicamtiv (MYK-491) | Danicamtiv (MYK-491, SAR 440181) is a novel and selective cardiac myosin allosteric activator that enhances cardiomyocyte contraction. |
| M19970 | Aficamten (CK-274) | Aficamten (CK-274, CK 3773274) is a novel cardiac myosin inhibitor that reduces myocardial contractile force in vitro and in vivo with an IC50 of 1.4 μM. |
| M10262 | Mavacamten (MYK-461) | Mavacamten, also known as SAR-439152 and MYK-461, is the first (first-class) orally bioavailable allosteric and reversible selective inhibitor of Cardiac Myosin. The IC50 of bovine heart and human heart was 490 nM and 711 nM, respectively. |
| M8430 | TR100 | TR100 is a specific anti-tropomyosin agent that preferentially disrupts the actin cytoskeleton of tumor cells. TR100 selectively disrupts Tm5NM1/2 containing actin filaments. |
| M7624 | 2,3-Butanedione monoxime | 2,3-Butanedione Monoxime (BDM) is a myosin ATPASE inhibitor. 2,3-Butanedione Monoxime is a skeletal and cardiac muscle contraction inhibitor. 2,3-Butanedione monoxime induces sarcoplasmic reticulum Ca2+ release. |
| M2004 | Omecamtiv mecarbil | Omecamtiv Mecarbil is a First-In-Class selective small molecule cardiac myosin activator that directly targets the contractile machinery of the heart, binding and increasing the number of cardiac myosin head regions interacting with actin during contraction. |
| M53320 | Myosin Light Chain Kinase Substrate (smooth muscle) | Myosin Light Chain Kinase Substrate (smooth muscle) is a smooth muscle myosin light chain kinase (MLCK) synthetic peptide substrate. |
| M53319 | Kemptamide | Kemptamide, a 13 amino acid fragment with a sequence corresponding to residues 11-23 of gizzard light chain. |
| M49439 | MYK-224 | MYK-224 is a cardiac myosin complex modulator that can be used in studies related to cardiovascular disease. |
| M41633 | Myosin V-IN-1 | Myosin V-IN-1 is a potent and selective Myosin V inhibitor, with a Ki of 6 μM. |
| M40570 | 16-38-Thymosin β4 (cattle) | 16-38-Thymosin β4 (cattle) is a high-affinity non-Ca2+-dependent MLCK activator. |
| M30504 | Pentachloropseudilin | Pentachloropseudilin (Antibiotic A 15104 Y; PClP) is a reversible and allosteric potent inhibitor of Myo1s (class 1 myosins) with IC50s range from 1 to 5 μM for mammalian class-1 myosins and greater than 90 μM for class-2 and class-5 myosins. Pentachloropseudilin is a potent inhibitor of transforming growth factor-β (TGF-β)-stimulated signaling, with an IC50 of 0.1 to 0.2 μM for TGF-β. |
| M29641 | ATM-3507 trihydrochloride | ATM-3507 trihydrochloride is a potent tropomyosin inhibitor with IC50s from 3.83-6.84 μM in human melanoma cell lines. |
| M29221 | Para-aminoblebbistatin | Para-aminoblebbistatin is a highly water soluble, non-fluorescent and photostable C15 amino-substituted derivative of blebbistatin; inhibits various (myosin II) isoforms both in vitro and in vivo. |
| M28705 | para-Nitroblebbistatin | para-Nitroblebbistatin is a non-cytotoxic, photostable, fluorescent and specific Myosin II inhibitor, usd in the study of the specific role of myosin II in physiological, developmental, and cell biological studies. |
| M28544 | MS-444 | MS-444 inhibits the activity of purified smooth muscle myosin light chain kinase (MLCK) with an IC50 value of 10 μM. |
| M13758 | MLCK inhibitor peptide 18 | MLCK inhibitor peptide 18 is a myosin light chain kinase (MLCK) inhibitor with an IC50 of 50 nM, and inhibits CaM kinase II only at 4000-fold higher concentrations. |
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