All AbMole products are for research use only, cannot be used for human consumption.
(±)-Blebbistatin (BLEB) is a small cell permeable selective myosin II inhibitor. Rabbit arterial SM was potently inhibited by BLEB (IC50 ∼5 µM) although this tissue does not express significant amounts of NMM II. Blebbistatin (BLEB) inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Blebbistatin (BLEB) rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.
Due to the known light sensitivity of Blebbistatin (BLEB), it was always kept in the dark in the refrigerator until just prior to usage.
Sci China Life Sci. 2022 Oct;65(10):2031-2049.
Mechanical transmission enables EMT cancer cells to drive epithelial cancer cell migration to guide tumor spheroid disaggregation
Blebbistain purchased from AbMole
| Molecular Weight | 292.34 |
| Formula | C18H16N2O2 |
| CAS Number | 674289-55-5 |
| Solubility (25°C) | DMSO ≥ 15 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
| Related Myosin Products |
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| Ulacamten
Ulacamten is a potent cardiac myosin inhibitor. |
| Myosin Light Chain Kinase Substrate (smooth muscle)
Myosin Light Chain Kinase Substrate (smooth muscle) is a smooth muscle myosin light chain kinase (MLCK) synthetic peptide substrate. |
| Kemptamide
Kemptamide, a 13 amino acid fragment with a sequence corresponding to residues 11-23 of gizzard light chain. |
| MYK-224
MYK-224 is a cardiac myosin complex modulator that can be used in studies related to cardiovascular disease. |
| Myosin V-IN-1
Myosin V-IN-1 is a potent and selective Myosin V inhibitor, with a Ki of 6 μM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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