About 32 results found for searched term "Myosin" (0.158 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M41633 | Myosin V-IN-1 | Myosin |
| Myosin V-IN-1 is a potent and selective Myosin V inhibitor, with a Ki of 6 μM. | ||
| M51356 | Myosin light chain kinase fragment 11-19 amide | Others |
| Myosin light chain kinase fragment 11-19 amide (MLCK(11-19) amide) is a substrate-specific peptide inhibitor of MLCK. | ||
| M53320 | Myosin Light Chain Kinase Substrate (smooth muscle) | Myosin |
| Myosin Light Chain Kinase Substrate (smooth muscle) is a smooth muscle myosin light chain kinase (MLCK) synthetic peptide substrate. | ||
| M2004 | Omecamtiv mecarbil | Myosin |
| CK-1827452 | ||
| Omecamtiv Mecarbil is a First-In-Class selective small molecule cardiac myosin activator that directly targets the contractile machinery of the heart, binding and increasing the number of cardiac myosin head regions interacting with actin during contraction. | ||
| M2459 | (-)-Blebbistatin | Myosin |
| (S)-(-)-Blebbistatin | ||
| (-)-Blebbistatin is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M6211 | LOXO-101 sulfate | Trk |
| Larotrectinib sulfate; ARRY-470 sulfate | ||
| LOXO-101 sulfate is an oral potent and selective ATP-competitive inhibitor of tropomyosin receptor kinases (TRK). | ||
| M6562 | Cardiogenol C hydrochloride | Others |
| Cardiogenol C HCl; CAS#: 671225-39-1 (free base) | ||
| Cardiogenol C hydrochloride is a diaminopyrimidine compound that induces the differentiation of MHC- (myosin heavy chain) positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 µM. | ||
| M7481 | W-7 hydrochloride | CaMK |
| W7 hydrochloride | ||
| W-7 Hydrochloride is a selective calmodulin antagonist. W-7 Hydrochloride inhibits Ca2+ -calmodulin-dependent phosphodiesterase and Myosin light chain kinase. The IC50 values were 28 μM and 51 μM, respectively. W-7 Hydrochloride can induce apoptosis and has anti-cancer activity. | ||
| M7590 | A3 hydrochloride | PKA |
| A-3 hydrochloride | ||
| A-3 Hydrochloride is A potent, cellular permeable, reversible, atP-competitive, non-selective antagonist targeting multiple kinases. A-3 Hydrochloride is an inhibitor of PKA (Ki=4.3 µM), casein kinase II (Ki=5.1 µM), and myosin light chain kinase (MLCK) (Ki=7.4 µM). A-3 hydrochloride also inhibited PKC and casein kinase I activity with Ki of 47 µM and 80 µM, respectively. | ||
| M7624 | 2,3-Butanedione monoxime | Myosin |
| Biacetyl monoxime; Diacetyl monoxime; DAM | ||
| 2,3-Butanedione Monoxime (BDM) is a myosin ATPASE inhibitor. 2,3-Butanedione Monoxime is a skeletal and cardiac muscle contraction inhibitor. 2,3-Butanedione monoxime induces sarcoplasmic reticulum Ca2+ release. | ||
| M7690 | ML-9 | Autophagy |
| ML-9 is a potent, selective Akt kinase inhibitor that inhibits myosin light chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity. It acts on MLCK, PKA and PKC with Ki values of 4, 32 and 54 μM, respectively. In addition, ML-9 induces autophagy by stimulating the formation of autophagosomes and inhibiting their degradation. | ||
| M8104 | PF-06683324 | Trk |
| PF-6683324 | ||
| PF-0668324 is pan tropomyosin-related kinase (Trk) inhibitor. | ||
| M8105 | PF-06737007 | Trk |
| PF-6737007 | ||
| PF-06737007 is pan tropomyosin-related kinase (Trk) inhibitor. | ||
| M8106 | PF-06733804 | Trk |
| PF-6733804 | ||
| PF-06733804 is pan tropomyosin-related kinase (Trk) inhibitor. | ||
| M8430 | TR100 | Myosin |
| TR-100 | ||
| TR100 is a specific anti-tropomyosin agent that preferentially disrupts the actin cytoskeleton of tumor cells. TR100 selectively disrupts Tm5NM1/2 containing actin filaments. | ||
| M9636 | Blebbistain | Myosin |
| BLEB; (±)-Blebbistatin | ||
| (±)-Blebbistatin (BLEB) is a small cell permeable selective myosin II inhibitor which potently relaxed normal detrusor smooth muscle. | ||
| M10262 | Mavacamten (MYK-461) | Myosin |
| SAR-439152; MYK-461 | ||
| Mavacamten, also known as SAR-439152 and MYK-461, is the first (first-class) orally bioavailable allosteric and reversible selective inhibitor of Cardiac Myosin. The IC50 of bovine heart and human heart was 490 nM and 711 nM, respectively. | ||
| M13409 | ATM-3507 trihydrochloride | Myosin |
| ATM-3507 is a potent inhibitor of Tropomyosin with an IC50 value of 3.83-6.84μM in human melanoma cell lines. | ||
| M13754 | OSU-T315 | Integrin |
| OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain). | ||
| M13758 | MLCK inhibitor peptide 18 | Myosin |
| MLCK inhibitor peptide 18 is a myosin light chain kinase (MLCK) inhibitor with an IC50 of 50 nM, and inhibits CaM kinase II only at 4000-fold higher concentrations. | ||
| M19970 | Aficamten (CK-274) | Myosin |
| CK-3773274; CK-274 | ||
| Aficamten (CK-274, CK 3773274) is a novel cardiac myosin inhibitor that reduces myocardial contractile force in vitro and in vivo with an IC50 of 1.4 μM. | ||
| M20084 | WAY-320008 | Others |
| WAY-320008 is a tropomyosin-related kinase a inhibitor | ||
| M20341 | WAY-300063 | Others |
| WAY-300063 is a inhibitor of Tropomyosin-Related Kinase A. | ||
| M21004 | Danicamtiv (MYK-491) | Myosin |
| SAR 440181 | ||
| Danicamtiv (MYK-491, SAR 440181) is a novel and selective cardiac myosin allosteric activator that enhances cardiomyocyte contraction. | ||
| M24972 | Bedinvetmab | Trk |
| ZTS-00508841 | ||
| Bedinvetmab (ZTS-00508841) is a canine monoclonal antibody (mAb) targeting nerve growth factor (NGF). Bedinvetmab inhibits NGF interaction with tropomyosin receptor kinase A (trkA) and p75 neurotrophin receptor (p75NTR) receptors. Bedinvetmab can be used for the research of osteoarthritis pain in dogs. | ||
| M28544 | MS-444 | Myosin |
| BE-34776 | ||
| MS-444 inhibits the activity of purified smooth muscle myosin light chain kinase (MLCK) with an IC50 value of 10 μM. | ||
| M28705 | para-Nitroblebbistatin | Myosin |
| para-Nitroblebbistatin is a non-cytotoxic, photostable, fluorescent and specific Myosin II inhibitor, usd in the study of the specific role of myosin II in physiological, developmental, and cell biological studies. | ||
| M29221 | Para-aminoblebbistatin | Myosin |
| Para-aminoblebbistatin is a highly water soluble, non-fluorescent and photostable C15 amino-substituted derivative of blebbistatin; inhibits various (myosin II) isoforms both in vitro and in vivo. | ||
| M29526 | Paltimatrectinib | Tyrosinase |
| Paltimatrectinib (compound I-147) is a potent tyrosine kinase inhibitor with an IC50 of <10 nM for tropomyosin kinases A (TrkA). Paltimatrectinib has the potential for cancer and inflammatory diseases. | ||
| M29641 | ATM-3507 trihydrochloride | Myosin |
| ATM-3507 trihydrochloride is a potent tropomyosin inhibitor with IC50s from 3.83-6.84 μM in human melanoma cell lines. | ||
| M30504 | Pentachloropseudilin | Myosin |
| Antibiotic A 15104 Y; PClP | ||
| Pentachloropseudilin (Antibiotic A 15104 Y; PClP) is a reversible and allosteric potent inhibitor of Myo1s (class 1 myosins) with IC50s range from 1 to 5 μM for mammalian class-1 myosins and greater than 90 μM for class-2 and class-5 myosins. Pentachloropseudilin is a potent inhibitor of transforming growth factor-β (TGF-β)-stimulated signaling, with an IC50 of 0.1 to 0.2 μM for TGF-β. | ||
| M49439 | MYK-224 | Myosin |
| MYK-224 is a cardiac myosin complex modulator that can be used in studies related to cardiovascular disease. | ||
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